ArticleSurgical endoscopy2013
The role of aerosolized intraperitoneal heparin and hyaluronic acid in the prevention of postoperative abdominal adhesions.
Article in Surgical endoscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Analysis of intestinal motility function regarding the combined effect of mosapride and trehalose in a paralytic ileus animal model.The Journal of veterinary medical science · 2026Article
- A Developmental Roadmap Toward Abdominal Adhesions Prevention Technologies.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Review
- The systemic effect and the absorption rate of aerosolized intra-peritoneal heparin with or without hyaluronic acid in the prevention of postoperative abdominal adhesions.Surgical endoscopy · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntraperitoneal adhesions are a common and serious problem following abdominal surgery. Significant research has been performed to investigate the mechanisms involved; however, this has not influenced the incidence; it is still the leading cause of intestinal obstruction, pelvic pain, and infertility in women. The purpose of this study was to evaluate the ability of aerosolized heparin and hyaluronic acid for the prevention of postoperative adhesions. MATERIALS AND
methodsA survival pig model was employed (N = 40). The pigs underwent laparoscopic insertion of polypropylene mesh to create intraperitoneal adhesions. The animals were randomized into four groups: control (n = 10), aerosolized heparin (n = 10), aerosolized hyaluronic acid (n = 10), and aerosolized mixture of both agents (n = 10). After a 2-week recovery period, the animals were killed and intraperitoneal adhesions were assessed.
resultsAll of the animals in the control group suffered postoperative adhesions (10/10) compared with three in the heparin group, two in the hyaluronic group, and one in the mixed group. The number of adhesions per animal and the severity was higher in the control group compared with the therapeutic groups. The mean number of adhesions in the affected pigs also was higher in the control group compared with the therapeutic groups: 3.3 versus 0.4 in heparin group (range 0-2) versus 0.3 in hyaluronic acid group versus 0.1 in the mixed group (p = 0.002).
conclusionsThis study has shown that aerosolised heparin and hyaluronic acid is an effective method to prevent postoperative adhesions whether they were used independently or in synergism. However, the best result was when both agents mixed together compared with the control. A human-based study will be the next step to confirm the success of these agents.
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