ArticleInflammopharmacology2014
Anti-Proteus activity of some South African medicinal plants: their potential for the prevention of rheumatoid arthritis.
Article in Inflammopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 103 citations in OpenAlex.
- Pathogens in rheumatoid arthritis: epidemiological, mechanistic, and clinical insights.Biomarker research · 2026Review
- A Review of the Ethnomedicine, Phytochemistry, Pharmacology and Toxicological Studies onPlants (Basel, Switzerland) · 2025Review
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- Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Traditional uses, pharmacological activities, and phytochemical constituents of the genusFood science & nutrition · 2022Review
- Comparison of the antibacterial activity of Australian Terminalia spp. extracts against Klebsiella pneumoniae: a potential treatment for ankylosing spondylitis.Inflammopharmacology · 2022Article
- The role of resveratrol on rheumatoid arthritis: From bench to bedside.Frontiers in pharmacology · 2022Review
- A Review of Plant-Based Therapies for the Treatment of Urinary Tract Infections in Traditional Southern African Medicine.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Unravelling the Antibacterial Activity ofMolecules (Basel, Switzerland) · 2020Article
- Invasive Plants: Turning Enemies into Value.Molecules (Basel, Switzerland) · 2020Review
- Article
- Syzygium Cordatum Hochst. ex Krauss: An Overview of Its Ethnobotany, Phytochemistry and Pharmacological Properties.Molecules (Basel, Switzerland) · 2018Review
- LC-MS/MS Tandem Mass Spectrometry for Analysis of Phenolic Compounds and Pentacyclic Triterpenes in Antifungal Extracts of Terminalia brownii (Fresen).Antibiotics (Basel, Switzerland) · 2017Article
- Potency and selectivity indices of acetone leaf extracts of nine selected South African trees against six opportunistic Enterobacteriaceae isolates from commercial chicken eggs.BMC complementary and alternative medicine · 2017Article
- Review
- The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae).Inflammopharmacology · 2015Review
- The potential of selected Australian medicinal plants with anti-Proteus activity for the treatment and prevention of rheumatoid arthritis.Pharmacognosy magazine · 2015Article
- The potential of selected South African plants with anti-Klebsiella activity for the treatment and prevention of ankylosing spondylitis.Inflammopharmacology · 2015Article
- 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways.The Journal of pharmacology and experimental therapeutics · 2014Article
- Efficacy of some colloidal silver preparations and silver salts against Proteus bacteria, one possible cause of rheumatoid arthritis.Inflammopharmacology · 2014Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide variety of herbal remedies are used in traditional African medicine to treat rheumatoid arthritis (RA) and inflammation. Thirty-four extracts from 13 South African plant species with a history of ethnobotanical usage in the treatment of inflammation were investigated for their ability to control two microbial triggers for RA (Proteus mirabilis and Proteus vulgaris). Twenty-nine of the extracts (85.3 %) inhibited the growth of P. mirabilis and 23 of them tested (67.7 %) inhibited the growth of P. vulgaris. Methanol and water extracts of Carpobrotus edulis, Lippia javanica, Pelargonium viridflorum, Ptaeroxylon obliquum, Syzygium cordatum leaf and bark, Terminalia pruinoides, Terminalia sericea, Warburgia salutaris bark and an aqueous extract of W. salutaris leaf were effective Proteus inhibitors, with MIC values <2,000 μg/ml. The most potent extracts were examined by Reverse phase high performance liquid chromatography and UV-Vis spectroscopy for the presence of resveratrol. Only extracts from T. pruinoides and T. sericea contained resveratrol, indicating that it was not responsible for the anti-Proteus properties reported here. All extracts with Proteus inhibitory activity were also either non-toxic, or of low toxicity in the Artemia nauplii bioassay. The low toxicity of these extracts and their inhibitory bioactivity against Proteus spp. indicate their potential for blocking the onset of rheumatoid arthritis.
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