Evidence map›Paper›PMID 23877705›Full record

ArticleAntimicrobial agents and chemotherapy2013

Field-based flow cytometry for ex vivo characterization of Plasmodium vivax and P. falciparum antimalarial sensitivity.

B Russell, B Malleret, R Suwanarusk, C Anthony, S Kanlaya, Y L Lau, C J Woodrow, F Nosten, L Renia

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Characterizing Blood-Stage Antimalarial Drug MIC ValuesAntimicrobial agents and chemotherapy · 2018
    Trial
  2. Ethanolic Leaf Extract ofTropical medicine and infectious disease · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Cytotoxic CD8Nature medicine · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

B RussellDepartment of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
B Malleret
R Suwanarusk
C Anthony
S Kanlaya
Y L Lau
C J Woodrow
F Nosten
L Renia

Funding

Wellcome Trust 089275
6 · The paper itself

Abstract

Ex vivo antimalarial sensitivity testing in human malaria parasites has largely depended on microscopic determination of schizont maturation. While this microscopic method is sensitive, it suffers from poor precision and is laborious. The recent development of portable, low-cost cytometers has allowed us to develop and validate a simple, field-optimized protocol using SYBR green and dihydroethidium for the accurate and objective determination of antimalarial drug sensitivity in freshly isolated Plasmodium vivax and Plasmodium falciparum.

Indexed as

AntimalarialsFlow CytometryPlasmodium falciparumPlasmodium vivaxAntimalarials

Identifiers

PMID23877705
PMCPMC3811473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.