ArticleAntimicrobial agents and chemotherapy2013
Interaction of silver nanoparticles with serum proteins affects their antimicrobial activity in vivo.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 161 citations in OpenAlex.
- A Preliminary in-vitro Evaluation of Serum Capped Colloidal Silver Nanoparticles on Liver Cancer towards Development of Safe Personalized Nanomedicine.International journal of nanomedicine · 2026Article
- The Role of Silver and Silver-Based Products in Wound Management: A Review of Advances and Current Landscape.Journal of functional biomaterials · 2026Review
- Mechanistic Modeling of Size and Surface Charge Changes of Gold and Silver Nanoparticles during In Vitro Nanoparticle Protein Corona Formation.ACS pharmacology & translational science · 2025Article
- Impact of protein corona and light modulation on the antibacterial activity of light-activated silver nanoparticles.Journal of materials chemistry. B · 2025Article
- Apoptosis and cell cycle arrest of bone marrow cells by green-synthesized silver but not albumin nanoparticles.Toxicology reports · 2025Article
- Nonwoven fabric coated with cerium oxide nanoparticles for viral inactivation and transmission Inhibition.Scientific reports · 2025Article
- Identification and mitigation of blood's interference with the antimicrobial activity of AgNbO3 particles.PloS one · 2025Article
- Fabrication of sulphur-doped graphitic carbon nitride anchored Ag@AgCl electrocatalyst for the sensing of chloramphenicol.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Biosynthesis and Characterization of Silver Nanoparticles and Simvastatin Association in Titanium Biofilms.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Polyvinylpyrrolidone capped silver nanoparticles enhance the autophagic clearance of Acinetobacter baumannii from human pulmonary cells.Discover nano · 2024Article
- Green synthesis of silver nanoparticles by sweet cherry and its application against cherry spot disease.Heliyon · 2024Article
- Antibiotics-free compounds for managing carbapenem-resistant bacteria; a narrative review.Frontiers in pharmacology · 2024Review
- Role of the Human Serum Albumin Protein Corona in the Antimicrobial and Photothermal Activity of Metallic Nanoparticles againstACS omega · 2023Article
- Synergistic antibacterial effect of copper and silver nanoparticles and their mechanism of action.Scientific reports · 2023Article
- Saline extract ofToxicological research · 2023Article
- Advanced Hydrogels Combined with Silver and Gold Nanoparticles against Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2023Review
- Serum protein coating enhances the antisepsis efficacy of silver nanoparticles against multidrug-resistantFrontiers in microbiology · 2023Article
- Silver Nanoparticle-Based Therapy: Can It Be Useful to Combat Multi-Drug Resistant Bacteria?Antibiotics (Basel, Switzerland) · 2022Review
- Comparative Analysis of the Mechanism of Resistance to Silver Nanoparticles and the Biocide 2,2-Dibromo-3-Nitrilopropionamide.Antimicrobial agents and chemotherapy · 2022Article
- Nanotechnology for Targeted Detection and Removal of Bacteria: Opportunities and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of multidrug-resistant bacteria is a global threat for human society. There exist recorded data that silver was used as an antimicrobial agent by the ancient Greeks and Romans during the 8th century. Silver nanoparticles (AgNPs) are of potential interest because of their effective antibacterial and antiviral activities, with minimal cytotoxic effects on the cells. However, very few reports have shown the usage of AgNPs for antibacterial therapy in vivo. In this study, we deciphered the importance of the chosen methods for synthesis and capping of AgNPs for their improved activity in vivo. The interaction of AgNPs with serum albumin has a significant effect on their antibacterial activity. It was observed that uncapped AgNPs exhibited no antibacterial activity in the presence of serum proteins, due to the interaction with bovine serum albumin (BSA), which was confirmed by UV-Vis spectroscopy. However, capped AgNPs [with citrate or poly(vinylpyrrolidone)] exhibited antibacterial properties due to minimized interactions with serum proteins. The damage in the bacterial membrane was assessed by flow cytometry, which also showed that only capped AgNPs exhibited antibacterial properties, even in the presence of BSA. In order to understand the in vivo relevance of the antibacterial activities of different AgNPs, a murine salmonellosis model was used. It was conclusively proved that AgNPs capped with citrate or PVP exhibited significant antibacterial activities in vivo against Salmonella infection compared to uncapped AgNPs. These results clearly demonstrate the importance of capping agents and the synthesis method for AgNPs in their use as antimicrobial agents for therapeutic purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.