ArticleEuropean journal of pediatrics2013
Use of analgesic and sedative drugs in VLBW infants in German NICUs from 2003-2010.
Article in European journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Sedation for less invasive surfactant administration in preterm infants: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2021Pooled it
- Trial
- Dexmedetomidine and midazolam usage and association with BSRI scores in preterm infants with chronic respiratory failure.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Cumulative exposure to opioids and benzodiazepines in extremely preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Use of narcotics and sedatives among very preterm infants in neonatal intensive care units in China: an observational cohort study.Translational pediatrics · 2023Article
- Opioids for procedural pain in neonates.The Cochrane database of systematic reviews · 2023Review
- Opioids for procedural pain in neonates.The Cochrane database of systematic reviews · 2023Review
- Frequencies, Modalities, Doses and Duration of Computerized Prescriptions for Sedative, Analgesic, Anesthetic and Paralytic Drugs in Neonates Requiring Intensive Care: A Prospective Pharmacoepidemiologic Cohort Study in 30 French NICUs From 2014 to 2020.Frontiers in pharmacology · 2022Article
- Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?The Journal of pediatrics · 2021Review
- Drug Utilisation and Off-Label Use on a German Neonatal Intensive Care Unit: A Retrospective Cohort Study and 10-Year Comparison.Pharmacy (Basel, Switzerland) · 2020Article
- A Critical Review on the Relevance of Paracetamol for Procedural Pain Management in Neonates.Frontiers in pediatrics · 2020Review
- Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study.European journal of pediatrics · 2018Observational
- Large differences in neonatal drug use between NICUs are common practice: time for consensus?British journal of clinical pharmacology · 2018Article
- Continuous positive airway pressure delivery during less invasive surfactant administration: a physiologic study.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Clinical pharmacology of analgosedatives in neonates: ways to improve their safe and effective use.The Journal of pharmacy and pharmacology · 2017Review
- Assessment of atropine-sufentanil-atracurium anaesthesia for endotracheal intubation: an observational study in very premature infants.BMC pediatrics · 2014Observational
- Decreasing Chronic Lung Disease Associated with Bubble CPAP Technology: Experience at Five Years.Pediatric quality & safetyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledVery low birth weight (VLBW) infants frequently receive analgesia and/or sedation for painful procedures and mechanical ventilation to avoid negative stress. Yet, concerns remain regarding potential adverse long-term effects of these drugs on VLBW infants' neurocognitive outcome. Recent studies have shown that less invasive surfactant application (LISA) and early nasal CPAP treatment reduce the need for mechanical ventilation and painful procedures. Therefore, these measures might also reduce the application of analgesic and/or sedative drugs in VLBW infants. To evaluate this hypothesis and to identify potential changes in analgesic treatment concepts in recent years, we retrospectively analyzed data on analgesia and sedation, respiratory support, and the method of surfactant application in VLBW infants enrolled in the German Neonatal Network (GNN) trial between 2003 and 2009 (period 1) and compared it with data from infants participating in GNN in 2010 (period 2). In both periods, about one third of all infants were treated with analgesic and/or sedative drugs using a wide variety of substances. The administration of novel drugs such as propofol, sufentanil, or intravenous paracetamol was higher in 2010 (6.7 vs. 12.2 %). Infants who were treated with CPAP only received significantly less analgesic/sedative medication than infants who were mechanically ventilated (12 vs. 65 %, p=<0.001). Similarly, infants treated with LISA received less analgesic or sedative drugs as compared to infants who received surfactant via endotracheal intubation (36 vs. 63 %, p=0.001).
conclusionAlthough both avoidances of mechanical ventilation and less invasive surfactant application are associated with reduced analgesic or sedative treatment, the percentage of VLBW infants who received analgesia and/or sedation remained unchanged in Germany in recent years.
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