ArticleInternational journal of public health2013
Can 8-hydroxy-2'-deoxyguanosine be used to assess oxidative stress caused by particulate matter air pollution in the general population?
Article in International journal of public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAssess the association between 8-hydroxy-2'-deoxyguanosine (8OHdG) levels and particulate matter air pollution in non-occupational exposure groups from peer-reviewed literature.
methodsOvid Medline and PubMed were used to search for all peer-reviewed articles published between 1946 and May 2013. Keywords included particulate matter, air pollution, deoxyguanosine, 8-hydroxy-2'-deoxyguanosine, and known abbreviations. Seven English, non-occupational exposure, human subject studies were evaluated.
resultsOf the two studies involving children one found significant positive associations between exposure to particulate matter air pollution and 8OHdG. Investigations into non-occupationally exposed adults were mixed. The lone double-blind crossover study found no relationship between diesel exhaust exposure and 8OHdG. Two out of three panel studies and one cohort study found significant associations between 8OHdG and classes of particles and for various lags.
conclusionsAnalyses accounting for particle composition and lags between exposure and physiological responses had the strongest significant associations. Results are not conclusive due to the inconsistency in study designs, small sample sizes, and differences in exposure assessment techniques. Consistent methodology with representative populations including women and other non-occupationally exposed groups are recommended.
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Registered trials
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