ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting Sirt1.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- miR‑126 overexpression attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human umbilical vein endothelial cells.Molecular medicine reports · 2021Article
- Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases.International journal of molecular sciences · 2020Review
- miRNA signatures in childhood sarcomas and their clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Review
- Prognostic significance of circulating microRNA-214 and -126 in dogs with appendicular osteosarcoma receiving amputation and chemotherapy.BMC veterinary research · 2019Article
- Small non-coding RNAs-based bone regulation and targeting therapeutic strategies.Molecular and cellular endocrinology · 2017Review
- Therapeutic applications of histone deacetylase inhibitors in sarcoma.Cancer treatment reviews · 2017Review
- Overexpression of miR-664 is associated with enhanced osteosarcoma cell migration and invasion ability via targeting SOX7.Clinical and experimental medicine · 2017Article
- MicroRNA-126 enhances the sensitivity of osteosarcoma cells to cisplatin and methotrexate.Oncology letters · 2015Article
- MicroRNA‑20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing early growth response 2 expression.Molecular medicine reports · 2015Article
- MicroRNA screening identifies circulating microRNAs as potential biomarkers for osteosarcoma.Oncology letters · 2015Article
- Tissue microRNA-126 expression level predicts outcome in human osteosarcoma.Diagnostic pathology · 2015Article
- MiR-374a promotes the proliferation of human osteosarcoma by downregulating FOXO1 expression.International journal of clinical and experimental medicine · 2015Article
- A polymorphism site in the pre‑miR‑34a coding region reduces miR‑34a expression and promotes osteosarcoma cell proliferation and migration.Molecular medicine reports · 2014Article
- miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- MiR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- miR-199a-3p negatively regulates the progression of osteosarcoma through targeting AXL.American journal of cancer research · 2014Article
- miR-126 functions as a tumor suppressor in osteosarcoma by targeting Sox2.International journal of molecular sciences · 2013Article
- Association of microRNA-126 expression with clinicopathological features and the risk of biochemical recurrence in prostate cancer patients undergoing radical prostatectomy.Diagnostic pathology · 2013Article
Corrections and comments
- Retraction · 2017-04-20Compromised Peer Review · Investigation by Journal/Publisher · · Journal published by SAGE starting in 2017
- Retracted
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have recently suggested that miRNAs contribute to the development of various types of human cancer as well as to their proliferation and metastasis. The aim of this study was to investigate the functional significance of miR-126 and to identify its possible target genes in osteosarcoma (OS) cells. Here, we found that expression level of miR-126 was reduced in osteosarcoma cells in comparison with the adjacent normal tissues. The enforced expression of miR-126 was able to inhibit cell proliferation in U2OS and MG63 cells, while miR-126 antisense oligonucleotides (antisense miR-126) promoted cell proliferation. At the molecular level, our results further revealed that expression of Sirt1, a member of histone deacetylase, was negatively regulated by miR-126. Therefore, the data reported here demonstrate that miR-126 is an important regulator in osteosarcoma, which will contribute to better understanding of the important misregulated miRNAs in osteosarcoma cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.