ArticleNucleic acids research2013
The PRP6-like splicing factor STA1 is involved in RNA-directed DNA methylation by facilitating the production of Pol V-dependent scaffold RNAs.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Intragenic methylation repatterning is associated with alternative splicing and unique epigenetic phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Intragenic methylation repatterning is associated with alternative splicing and unique epigenetic phenotypes.Environmental epigenetics · 2026Article
- RNA interference and turnover in plants -a complex partnership.Frontiers in plant science · 2025Review
- Distinct small RNAs are expressed at different stages ofFrontiers in genetics · 2024Article
- Analysis of the Arabidopsis coilin mutant reveals a positive role of AtCOILIN in plant immunity.Plant physiology · 2022Article
- A genetic screen in Arabidopsis reveals the identical roles for RBP45d and PRP39a in 5' cryptic splice site selection.Frontiers in plant science · 2022Article
- Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions.Frontiers in plant science · 2022Review
- MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset of target regions of RNA-directed DNA methylation.The Plant journal : for cell and molecular biology · 2021Article
- To Splice or to Transcribe: SKIP-Mediated Environmental Fitness and Development in Plants.Frontiers in plant science · 2019Review
- Ovule Gene Expression Analysis in Sexual and Aposporous ApomicticFrontiers in plant science · 2019Article
- Dynamics and function of DNA methylation in plants.Nature reviews. Molecular cell biology · 2018Review
- Splicing regulation by long noncoding RNAs.Nucleic acids research · 2018Review
- Hidden Effects of Seed Quality Breeding on Germination in Oilseed Rape (Frontiers in plant science · 2018Article
- STABILIZED1 Modulates Pre-mRNA Splicing for Thermotolerance.Plant physiology · 2017Article
- Alternative Splicing in Plant Genes: A Means of Regulating the Environmental Fitness of Plants.International journal of molecular sciences · 2017Review
- Genetic Screening for Arabidopsis Mutants Defective in STA1 Regulation under Thermal Stress Implicates the Existence of Regulators of Its Specific Expression, and the Genetic Interactions in the Stress Signaling Pathways.Frontiers in plant science · 2016Article
- RNA-directed DNA methylation in plants.Plant cell reports · 2015Article
- SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis.Cell research · 2014Article
- Noncoding RNAs and DNA Methylation in Plants.National science review · 2014Article
- RNA Splicing Factors and RNA-Directed DNA Methylation.Biology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is a conserved epigenetic marker in plants and animals. In Arabidopsis, DNA methylation can be established through an RNA-directed DNA methylation (RdDM) pathway. By screening for suppressors of ros1, we identified STA1, a PRP6-like splicing factor, as a new RdDM regulator. Whole-genome bisulfite sequencing suggested that STA1 and the RdDM pathway share a large number of common targets in the Arabidopsis genome. Small RNA deep sequencing demonstrated that STA1 is predominantly involved in the accumulation of the siRNAs that depend on both Pol IV and Pol V. Moreover, the sta1 mutation partially reduces the levels of Pol V-dependent RNA transcripts. Immunolocalization assay indicated that STA1 signals are exclusively present in the Cajal body and overlap with AGO4 in most nuclei. STA1 signals are also partially overlap with NRPE1. Localization of STA1 to AGO4 and NRPE1 signals is probably related to the function of STA1 in the RdDM pathway. Based on these results, we propose that STA1 acts downstream of siRNA biogenesis and facilitates the production of Pol V-dependent RNA transcripts in the RdDM pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.