ReviewJournal of cardiovascular translational research2013
Coronary flow reserve from mouse to man--from mechanistic understanding to future interventions.
Review in Journal of cardiovascular translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Coronary Microvascular Dysfunction in Patients with Congenital Heart Disease.Current cardiology reviews · 2023Pooled it
- Coronary flow velocity reserve by echocardiography: feasibility, reproducibility and agreement with PET in overweight and obese patients with stable and revascularized coronary artery disease.Cardiovascular ultrasound · 2016Trial
- Systolic-dominant coronary flow in rats and mice: Challenging the diastolic paradigm across conscious and anaesthetized states.Experimental physiology · 2026Article
- p53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Simplified coronary flow reserve calculations based on three-dimensional coronary reconstruction and intracoronary pressure data.Cardiology journal · 2023Article
- Role of sex hormones in modulating myocardial perfusion and coronary flow reserve.European journal of nuclear medicine and molecular imaging · 2022Article
- Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice.Journal of visualized experiments : JoVE · 2022Article
- Regulatory role of TIGAR on endothelial metabolism and angiogenesis.Journal of cellular physiology · 2021Article
- The Holistic Coronary Physiology Display: Calculation of the Flow Separation Index in Vessel-Specific Individual Flow Range during Fractional Flow Reserve Measurement Using 3D Coronary Reconstruction.Journal of clinical medicine · 2021Article
- Histone Acetyltransferase p300 Inhibitor Improves Coronary Flow Reserve in SIRT3 (Sirtuin 3) Knockout Mice.Journal of the American Heart Association · 2020Article
- Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation.Annals of translational medicine · 2020Article
- Coronary Microvascular Dysfunction in HIV: A Review.Journal of the American Heart Association · 2020Review
- SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/obCardiovascular diabetology · 2019Article
- PROspective evaluation of coronary FLOW reserve and molecular biomarkers in patients with established coronary artery disease the PROFLOW-trial: cross-sectional evaluation of coronary flow reserve.Vascular health and risk management · 2019Article
- Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF.European heart journal · 2018Observational
- Article
- Incremental Value of Transthoracic Doppler Echocardiography-Assessed Coronary Flow Reserve in Patients With Suspected Myocardial Ischemia Undergoing Myocardial Perfusion Scintigraphy.Journal of the American Heart Association · 2017Article
- Determinants of coronary flow reserve in non-diabetic patients with chest pain without myocardial perfusion defects.PloS one · 2017Article
- Ultrasound based assessment of coronary artery flow and coronary flow reserve using the pressure overload model in mice.Journal of visualized experiments : JoVE · 2015Article
- Animal models of diabetic macrovascular complications: key players in the development of new therapeutic approaches.Journal of diabetes research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial ischemia is recognized as an important mechanism increasing the risk for cardiovascular events in both symptomatic and asymptomatic patients. In addition to obstructive coronary diseases, systemic inflammation, macro- and microvascular function are additional important mechanisms contributing to the ischemic myocardium. Accumulating evidence indicates that coronary flow reserve (CFR) is a quantitative measurement of ischemia including integrated information on structure and function of the coronary artery at all levels. Not surprisingly, CFR has been shown to confer strong prognostic value for hard cardiovascular (CV) events in a number of relevant patient cohorts. Using high-resolution imaging, it is now possible to study coronary arteries from mouse to man. Therefore, CFR may be an important translational tool to risk-stratify patients and to perform both preclinical and clinical proof-of-concept studies before investing in large-scale outcome trials, thus improving the translational value for novel CV targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.