SynthesisScientific reports2013
GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects.
Synthesis in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Glutathione-S-transferases M1/T1 gene polymorphisms and male infertility risk in Chinese populations: A meta-analysis.Medicine · 2019Pooled it
- The association between the rs6495309 polymorphism in CHRNA3 gene and lung cancer risk in Chinese: a meta-analysis.Scientific reports · 2014Pooled it
- Xenobiotic metabolizing gene variants and the risk of male infertility - A systematic review, meta-analysis andToxicology reports · 2025Review
- Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis.Biomolecules · 2025Review
- The moderation effect of GSTM1/GSTT1 gene polymorphisms on the association of sperm mitochondrial DNA copy number and sperm mobility.Scientific reports · 2024Article
- LanCL2 Implicates in Testicular Redox Homeostasis and Acrosomal Maturation.Antioxidants (Basel, Switzerland) · 2024Article
- Detection ofJournal of clinical medicine · 2023Article
- Association ofJournal of clinical medicine · 2023Article
- Beta-Meta: a meta-analysis application considering heterogeneity among genome-wide association studies.Genomics & informatics · 2022Article
- Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis.Lab animal · 2022Article
- Effect of glutathione S-transferase gene polymorphisms on semen quality in patients with idiopathic male infertility.The Journal of international medical research · 2021Article
- Glutathione S-transferase M1 and T1 null genotype frequency distribution among four tribal populations of western India.Journal of genetics · 2018Article
- The role of epigenetics in idiopathic male infertility.Journal of assisted reproduction and genetics · 2016Review
- Do Variants in GSTs Modify the Association between Traffic Air Pollution and Asthma in Adolescence?International journal of molecular sciences · 2016Article
- Copy number variations in high and low fertility breeding boars.BMC genomics · 2015Article
- Variations in Antioxidant Genes and Male Infertility.BioMed research international · 2015Review
- Association of Novel Single Nucleotide Polymorphisms of Genes Involved in Cell Functions with Male Infertility: A Study of Male Cases in Northwest Iran.Journal of reproduction & infertilityArticle
- Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives.Asian journal of andrologyArticle
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size case-control study, and conducted a literature-based meta-analysis of 6934 individuals. Our case-control study showed the GSTM1 null genotype was significantly associated with idiopathic oligozoospermia, while the null genotype of GSTT1 was significantly associated with normozoospermia and azoospermia. Additionally, significantly elevated GSTT1 expression levels were observed in present genotype compared with null genotype. In the meta-analysis, the null genotype of GSTM1 was associated with a significantly increased risk of male infertility. Furthermore, a stratification analysis showed that the risk of GSTM1 polymorphism was associated with male infertility in both Asian and Caucasian groups. Further studies of GSTM1 and GSTT1 with their biological functions are needed to understand the role of these genes in the development of male infertility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.