ReviewNutrients2013
Peculiarities of one-carbon metabolism in the strict carnivorous cat and the role in feline hepatic lipidosis.
Review in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 70 citations in OpenAlex.
- Beyond Body Condition Score: A Proposed Interspecies Framework for Tissue-by-Tissue Nutritional Assessment in Veterinary Practice.Veterinary sciences · 2026Review
- Review
- Evaluation of Serum Homocysteine and High-Sensitivity Cardiac Troponins in Cats with Hepatic Lipidosis: An Observational Clinical Study.Veterinary sciences · 2026Article
- Betaine Dietary Supplementation: Healthy Aspects in Human and Animal Nutrition.Antioxidants (Basel, Switzerland) · 2025Review
- Metabolomic profiling of serum alterations and biomarker discovery in feline hepatic liposis.Scientific reports · 2025Article
- Serum metabolomics reveals one-carbon metabolism differences between lean and obese cats not affected by L-carnitine or choline supplementation.Journal of animal science · 2025Article
- Hepatic lipidosis in nine African white-bellied pangolins (Frontiers in veterinary science · 2025Article
- Feline Cognition and the Role of Nutrition: An Evolutionary Perspective and Historical Review.Animals : an open access journal from MDPI · 2024Review
- Minimum methionine requirement in adult cats as determined by indicator amino acid oxidation.Journal of animal science · 2024Article
- Description of the fasted serum metabolomic signature of lean and obese cats at maintenance and of obese cats under energy restriction.PloS one · 2024Article
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- Article
- Dietary choline, but not L-carnitine, increases circulating lipid and lipoprotein concentrations, without affecting body composition, energy expenditure or respiratory quotient in lean and obese male cats during weight maintenance.Frontiers in veterinary science · 2023Article
- Choline supplementation regulates gut microbiome diversity, gut epithelial activity, and the cytokine gene expression in gilts.Frontiers in nutrition · 2023Article
- Dietary Betaine Interacts with Very Long Chain n-3 Polyunsaturated Fatty Acids to Influence Fat Metabolism and Circulating Single Carbon Status in the Cat.Animals : an open access journal from MDPI · 2022Article
- Metabolomic changes in cats with renal disease and calcium oxalate uroliths.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Pegylated asparaginase in feline high-grade lymphoma: clinical results of single injection and continued incorporation into a modified COP regimen.Journal of feline medicine and surgery · 2022Article
- Dose-response relationship between dietary choline and serum lipid profile, energy expenditure, and respiratory quotient in overweight adult cats fed at maintenance energy requirements.Journal of animal science · 2022Article
- Chronic Stress-Related Gastroenteric Pathology in Cheetah: Relation between Intrinsic and Extrinsic Factors.Biology · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research in various species has indicated that diets deficient in labile methyl groups (methionine, choline, betaine, folate) produce fatty liver and links to steatosis and metabolic syndrome, but also provides evidence of the importance of labile methyl group balance to maintain normal liver function. Cats, being obligate carnivores, rely on nutrients in animal tissues and have, due to evolutionary pressure, developed several physiological and metabolic adaptations, including a number of peculiarities in protein and fat metabolism. This has led to specific and unique nutritional requirements. Adult cats require more dietary protein than omnivorous species, maintain a consistently high rate of protein oxidation and gluconeogenesis and are unable to adapt to reduced protein intake. Furthermore, cats have a higher requirement for essential amino acids and essential fatty acids. Hastened use coupled with an inability to conserve certain amino acids, including methionine, cysteine, taurine and arginine, necessitates a higher dietary intake for cats compared to most other species. Cats also seemingly require higher amounts of several B-vitamins compared to other species and are predisposed to depletion during prolonged inappetance. This carnivorous uniqueness makes cats more susceptible to hepatic lipidosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.