Evidence map›Paper›PMID 23876683›Full record

ReviewHuman immunology2013

Moving beyond HLA: a review of nHLA antibodies in organ transplantation.

Tara K Sigdel, Minnie M Sarwal

Open access · greenAbstract readReview
In one paragraph

Review in Human immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Kidney transplantation in highly sensitized recipients.Kidney research and clinical practice · 2021
    Article
  4. Article
  5. Transplant glomerulopathy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018
    Review
  6. Observational
  7. Associations betweenOncotarget · 2017
    Article
  8. Article
  9. Advances in diagnostics for transplant rejection.Expert review of molecular diagnostics · 2016
    Review
  10. Review
  11. Review
  12. Article
  13. Endothelial cell antibodies associated with novel targets and increased rejection.Journal of the American Society of Nephrology : JASN · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tara K SigdelCalifornia Pacific Medical Center, Research Institute, San Francisco, CA, USA.
Minnie M Sarwal
California Pacific Medical Center · US

Funding

Noninvasive Markers and Transplant Outcome in HumansU01AI063594 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2004 to 2022
$66.5M
Urinary Proteome Monitoring for Transplant InjuryR01DK083447 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CAMP, DAVID G, SARWAL, MINNIE M · 2010 to 2013
$2.4M
Defining Biomarkers in Pediatric Renal TransplantationR01AI061739 · NIAID · STANFORD UNIVERSITY · PI SARWAL, MINNIE M · 2004 to 2007
$1.6M
Novel Urinary Proteomic Biomarkers for Acute Renal Transplant RejectionR21AI075256 · NIAID · STANFORD UNIVERSITY · PI SARWAL, MINNIE M · 2009 to 2010
$440k
NIAID NIH HHS R01 AI061739NIAID NIH HHS R21 AI075256NIAID NIH HHS U01 AI063594NIAID NIH HHS U01 AI063594-06NIDDK NIH HHS R01 DK083447NIDDK NIH HHS R01 DK083447-01A2
6 · The paper itself

Abstract

Given the finite graft life expectancy of HLA identical organ transplants and the recognition of humoral graft injury in the absence of donor directed anti-HLA antibodies, the clinical impact of antibodies against non-HLA (nHLA) antigens in transplant injury is being increasingly recognized. The recognition of the impact of nHLA antigen discrepancies between donor and recipient on transplant outcomes is timely given the advances in rapid and lower cost sequencing methods that can soon provide complete maps of all recipient and donor HLA and nHLA mismatch data. In this review, we present a summary of recent reports evaluating the role of nHLA antibodies and their relevance to the field of organ transplantation.

Indexed as

Organ TransplantationAnimalsAntibodiesEpitope MappingGraft RejectionHistocompatibilityHLA AntigensHumansIsoantigensPostoperative ComplicationsAntibodiesHLA AntigensIsoantigens

Identifiers

PMID23876683
PMCPMC5221517
OpenAlexW1968123142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.