ReviewPhysics of life reviews2013
How life changes itself: the Read-Write (RW) genome.
Review in Physics of life reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 147 citations in OpenAlex.
- Mammalian-evolved strains of the fungal pathogen Cryptococcus neoformans show adaptation via heritable transcript level differences specific to mouse MHC haplotype.BMC genomics · 2026Article
- Agency as an Inherent Property of Living Organisms.Biological theory · 2024Review
- Vitalism and cognition in a conscious universe.Communicative & integrative biology · 2022Article
- Non-Random Genome Editing and Natural Cellular Engineering in Cognition-Based Evolution.Cells · 2021Review
- Genomic Intelligence as Über Bio-Cybersecurity: The Gödel Sentence in Immuno-Cognitive Systems.Entropy (Basel, Switzerland) · 2021Article
- The emerging role of cell-free DNA as a molecular marker for cancer management.Biomolecular detection and quantification · 2019Review
- Review
- A systematic approach to cancer: evolution beyond selection.Clinical and translational medicine · 2017Article
- Biological action in Read-Write genome evolution.Interface focus · 2017Review
- A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles.Cellular and molecular life sciences : CMLS · 2016Review
- Nothing in Evolution Makes Sense Except in the Light of Genomics: Read-Write Genome Evolution as an Active Biological Process.Biology · 2016Review
- Just how Lamarckian is CRISPR-Cas immunity: the continuum of evolvability mechanisms.Biology direct · 2016Article
- Stochasticity and determinism in cancer creation and progression.Convergent science physical oncology · 2015Article
- The Lamarckian chicken and the Darwinian egg.Biology direct · 2015Article
- Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics.Molecular biology reports · 2015Article
- RNA sociology: group behavioral motifs of RNA consortia.Life (Basel, Switzerland) · 2014Review
- You cannot tell a book by looking at the cover: Cryptic complexity in bacterial evolution.Biomicrofluidics · 2014Article
- Pragmatic turn in biology: From biological molecules to genetic content operators.World journal of biological chemistry · 2014Review
- Physiology of the read-write genome.The Journal of physiology · 2014Review
- Cross-species gene-family fluctuations reveal the dynamics of horizontal transfers.Nucleic acids research · 2014Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genome has traditionally been treated as a Read-Only Memory (ROM) subject to change by copying errors and accidents. In this review, I propose that we need to change that perspective and understand the genome as an intricately formatted Read-Write (RW) data storage system constantly subject to cellular modifications and inscriptions. Cells operate under changing conditions and are continually modifying themselves by genome inscriptions. These inscriptions occur over three distinct time-scales (cell reproduction, multicellular development and evolutionary change) and involve a variety of different processes at each time scale (forming nucleoprotein complexes, epigenetic formatting and changes in DNA sequence structure). Research dating back to the 1930s has shown that genetic change is the result of cell-mediated processes, not simply accidents or damage to the DNA. This cell-active view of genome change applies to all scales of DNA sequence variation, from point mutations to large-scale genome rearrangements and whole genome duplications (WGDs). This conceptual change to active cell inscriptions controlling RW genome functions has profound implications for all areas of the life sciences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.