ArticleJournal of insect physiology2013
Silent, generic and plant kairomone sensitive odorant receptors from the Southern house mosquito.
Article in Journal of insect physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- A highly expressed odorant receptor from the yellow fever mosquito, AaegOR11, responds to (+)- and (-)-fenchone and a phenolic repellent.Insect biochemistry and molecular biology · 2022Article
- Mosquito odorant receptor sensitive to natural spatial repellents and inhibitory compounds.Insect biochemistry and molecular biology · 2022Article
- Article
- Odorant receptors from Culex quinquefasciatus and Aedes aegypti sensitive to floral compounds.Insect biochemistry and molecular biology · 2019Article
- A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET.PloS one · 2019Article
- Blood meal induced regulation of the chemosensory gene repertoire in the southern house mosquito.BMC genomics · 2017Article
- Functional and Nonfunctional Forms of CquiOR91, an Odorant Selectivity Subunit of Culex quinquefasciatus.Chemical senses · 2017Article
- Odorant receptor-based discovery of natural repellents of human lice.Insect biochemistry and molecular biology · 2015Article
- Multitasking roles of mosquito labrum in oviposition and blood feeding.Frontiers in physiology · 2015Article
- Mosquito odorant receptor for DEET and methyl jasmonate.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- An inhibitor of Na(+)/Ca(2+) exchange blocks activation of insect olfactory receptors.Biochemical and biophysical research communications · 2014Article
- Differential expression of olfactory genes in the southern house mosquito and insights into unique odorant receptor gene isoforms.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- RNAi-based demonstration of direct link between specific odorant receptors and mosquito oviposition behavior.Insect biochemistry and molecular biology · 2013Article
- Phenylthiophenecarboxamide antagonists of the olfactory receptor co-receptor subunit from a mosquito.PloS one · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The Southern house mosquito Culex quinquefasciatus has the largest repertoire of odorant receptors (ORs) of all mosquitoes and dipteran species whose genomes have been sequenced to date. Previously, we have identified and de-orphanized two ORs expressed in female antennae, CquiOR2 and CquiOR10, which are sensitive to oviposition attractants. In view of a new nomenclature for the Culex genome (VectorBase) we renamed these ORs as CquiOR21 (formerly CquiOR10) and CquiOR121 (CquiOR2). In addition, we selected ORs from six different phylogenetic groups for deorphanization. We cloned four of them by using cDNA from female antennae as a template. Attempts to clone CquiOR87 and CquiOR110 were unsuccessful either because they are pseudogenes or are not expressed in adult female antennae, the main olfactory tissue. By contrast, CquiOR1, CquiOR44, CquiOR73, and CquiOR161 were highly expressed in female antennae. To de-orphanize these ORs, we employed the Xenopus oocyte recording system. CquiORx-CquiOrco-expressed oocytes were challenged with a panel of 90 compounds, including known oviposition attractants, human and vertebrate host odorants, plant kairomones, and naturally occurring repellents. While CquiOR161 did not respond to any test compound in two different laboratories, CquiOR1 showed the features of a generic OR, with strong responses to 1-octen-3-ol and other ligands. CquiOR44 and CquiOR73 showed preference to plant-derived terpenoids and phenolic compounds, respectively. While fenchone was the best ligand for the former, 3,5-dimethylphenol elicited the strongest responses in the latter. The newly de-orphanized ORs may be involved in reception of plant kairomones and/or natural repellents.
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Registered trials
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