Evidence map›Paper›PMID 23876511›Full record

ArticleJournal of vascular surgery2014

Diet-induced obesity drives negative mouse vein graft wall remodeling.

Peng Yu, Binh T Nguyen, Ming Tao, Tianyu Jiang, C Keith Ozaki

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05457881 (Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05457881 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease

TypeinterventionalSponsorBrigham and Women's HospitalRan2024 to 2029Enrolled0ConditionsVascular Diseases, SurgeryArmsScandi-Shake
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Role of Perivascular Adipose Tissue in Vein Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Peng YuDivision of Vascular and Endovascular Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Mass.
Binh T NguyenDivision of Vascular and Endovascular Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Mass.
Ming TaoDivision of Vascular and Endovascular Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Mass.
Tianyu JiangDivision of Vascular and Endovascular Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Mass.
C Keith OzakiDivision of Vascular and Endovascular Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Mass. Electronic address: ckozaki@partners.org.
Brigham and Women's Hospital · USHarvard University · US

Funding

HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
Cytokine Driven Mechanisms of Vein Graft FailureR01HL079135 · NHLBI · UNIVERSITY OF FLORIDA · PI OZAKI, C KEITH · 2005 to 2009
$1.8M
NHLBI NIH HHS 1R01HL079135-06S1NHLBI NIH HHS R01 HL079135NHLBI NIH HHS R01HL079135NHLBI NIH HHS T32 HL007734NHLBI NIH HHS T32HL007734
6 · The paper itself

Abstract

introductionThe heightened inflammatory phenotype associated with obesity has been linked to the development of cardiovascular diseases. Short-term high-fat feeding induces a proinflammatory state that may impact the blood vessel wall. CD11c, a significantly increased dendritic cell biomarker during diet-induced obesity (DIO), may have a mechanistic role in this high-fat feeding effect. We hypothesized that the proinflammatory effect of short-term DIO accelerates vein bypass graft failure via CD11c-dependent mechanisms.

methodsMale 9-week-old DIO mice (n = 13, C57BL/6J recipients; n = 6, CD11c(-/-) recipients) and normal chow controls (n = 15, C57BL/6J recipients; n = 6, CD11c(-/-) recipients) underwent unilateral carotid interposition vein isografting (inferior vena cava from the same diet and genetic background donor), with a midgraft or outflow focal stenosis. Vein grafts were harvested at either 1 week (immunohistochemical staining for early CD11c expression) or 4 weeks later (morphometric analyses and CD11c evaluation).

resultsDespite a 40% larger body size, C57BL/6J DIO mice had 44% smaller poststenosis vein graft lumens (P = .03) than their controls via an acceleration of overall negative vein graft wall remodeling in the day-28 midgraft focal stenosis model but not in the outflow stenosis model. Higher CD11c expression occurred in DIO midgraft-stenosis vein graft walls, both at postoperative days 7 and 28. In contrast, with in vivo CD11c deficiency, DIO did not elicit this poststenotic negative remodeling but attenuated intimal hyperplasia.

conclusionsThese findings highlight negative wall remodeling as a potential factor leading to vein graft failure and provide direct evidence that short-term dietary alterations in the mammalian metabolic milieu can have lasting implications related to acute vascular interventions. DIO induces negative mouse vein graft wall remodeling via CD11c-depedent pathways.

Indexed as

AnimalsCarotid StenosisDietary FatsDisease Models, AnimalGraft Occlusion, VascularMaleMiceMice, Inbred C57BLObesityVena Cava, InferiorDietary Fats

Identifiers

PMID23876511
PMCPMC3823755
OpenAlexW1986630853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.