ArticleGenome biology2013
GLiMMPS: robust statistical model for regulatory variation of alternative splicing using RNA-seq data.
Article in Genome biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.Nature medicine · 2019Trial
- A deep dive into statistical modeling of RNA splicing QTLs reveals variants that explain neurodegenerative disease.American journal of human genetics · 2025Article
- Alternative Splicing Regulation in Metabolic Disorders.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Selecting differential splicing methods: Practical considerations for short-read RNA sequencing.F1000Research · 2025Review
- The impact of genetically controlled splicing on exon inclusion and protein structure.PloS one · 2024Article
- SEESAW: detecting isoform-level allelic imbalance accounting for inferential uncertainty.Genome biology · 2023Article
- The landscape of expression and alternative splicing variation across human traits.Cell genomics · 2023Article
- The RNA editing landscape in acute myeloid leukemia reveals associations with disease mutations and clinical outcome.iScience · 2022Article
- GPEdit: the genetic and pharmacogenomic landscape of A-to-I RNA editing in cancers.Nucleic acids research · 2022Article
- Switched alternative splicing events as attractive features in lung squamous cell carcinoma.Cancer cell international · 2022Article
- MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis.Nature communications · 2021Article
- Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes.Genome biology · 2021Article
- In silico identification of pseudo-exon activation events in personal genome and transcriptome data.RNA biology · 2021Article
- A transcription-centric model of SNP-age interaction.PLoS genetics · 2021Article
- Transcriptome analysis of alternative splicing in the pathogen life cycle in human foreskin fibroblasts infected with Trypanosoma cruzi.Scientific reports · 2020Article
- Detecting Allele-Specific Alternative Splicing from Population-Scale RNA-Seq Data.American journal of human genetics · 2020Article
- Regional Variation of Splicing QTLs in Human Brain.American journal of human genetics · 2020Article
- Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation.eLife · 2020Article
- Expression Changes Confirm Genomic Variants Predicted to Result in Allele-Specific, Alternative mRNA Splicing.Frontiers in genetics · 2020Article
- Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene.PLoS genetics · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To characterize the genetic variation of alternative splicing, we develop GLiMMPS, a robust statistical method for detecting splicing quantitative trait loci (sQTLs) from RNA-seq data. GLiMMPS takes into account the individual variation in sequencing coverage and the noise prevalent in RNA-seq data. Analyses of simulated and real RNA-seq datasets demonstrate that GLiMMPS outperforms competing statistical models. Quantitative RT-PCR tests of 26 randomly selected GLiMMPS sQTLs yielded a validation rate of 100%. As population-scale RNA-seq studies become increasingly affordable and popular, GLiMMPS provides a useful tool for elucidating the genetic variation of alternative splicing in humans and model organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.