Evidence map›Paper›PMID 2387629›Full record

ArticleInfection and immunity1990

Binding of Mycobacterium avium-Mycobacterium intracellulare to human leukocytes.

A Catanzaro, S D Wright

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

A CatanzaroDepartment of Medicine, University of California, San Diego 92103.
S D Wright
University of San Diego · US

Funding

THE INTERACTION OF MONOCYTES, T CELLS AND COMPONENTS OF THE VESSEL WALLP01AI024775 · NIAID · ROCKEFELLER UNIVERSITY · PI STEINMAN, RALPH M. · 1987 to 1995
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STRUCTURE AND FUNCTION OF HUMAN C3 RECEPTORSR01AI022003 · NIAID · ROCKEFELLER UNIVERSITY · PI WRIGHT, SAMUEL D · 1985 to 1991
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NIAID NIH HHS AI 22003NIAID NIH HHS AI 24775
6 · The paper itself

Abstract

We examined nonopsonic binding of Mycobacterium avium-Mycobacterium intracellulare (MAI) by human leukocytes. Macrophages (M phi) avidly bound fluorescently labeled MAI in the absence of serum proteins. Binding appeared to be mediated by a lineage-specific, proteinaceous receptor on M phi, since (i) binding of labeled bacteria could be competitively inhibited by unlabeled MAI, (ii) treatment of M phi with trypsin ablated the ability of M phi to bind MAI, and (iii) the capacity to bind MAI was observed on monocytes, M phi, and stimulated polymorphonuclear cells but not on lymphocytes or unstimulated polymorphonuclear cells. The receptor for MAI appeared mobile in the plane of the membrane, since spreading of M phi on a carpet of immobilized, unlabeled MAI down modulated binding of labeled MAI added in suspension. The receptor required neither calcium nor magnesium for activity and appeared different from other known receptors for intracellular pathogens.

Indexed as

Binding SitesCell MembraneCells, CulturedHumansKineticsLeukocytes, MononuclearMacrophagesMycobacterium avium ComplexNeutrophilsT-LymphocytesTrypsinTrypsin

Identifiers

PMID2387629
PMCPMC313593
OpenAlexW2166850677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.