Evidence map›Paper›PMID 23876218›Full record

ReviewTrends in microbiology2013

Illuminating the roles of the Borrelia burgdorferi adhesins.

Jenifer Coburn, John Leong, George Chaconas

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 88 citations in OpenAlex.

  1. Lyme borreliosis.Nature reviews. Disease primers · 2026
    Review
  2. Characterization ofMicroorganisms · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Tick-to-host transmission differs betweenMicrobiology spectrum · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Host Cell Binding Mediated byInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Identification of amino acid domains ofFrontiers in cellular and infection microbiology · 2022
    Article
  17. Article
  18. Lyme Disease Pathogenesis.Current issues in molecular biology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jenifer CoburnDivision of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jcoburn@mcw.edu
John Leong
George Chaconas
Medical College of Wisconsin · USTufts University · USUniversity of Calgary · CA

Funding

Comprehensive Analysis of Borrelia burgdorferi AdhesinsR01AI093104 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI CHACONAS, GEORGE, COBURN, JENIFER L · 2011 to 2015
$2.3M
Analysis of the Borrelia burgdorferi Integrin Ligand P66R01AI084873 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI COBURN, JENIFER L · 2012 to 2016
$1.9M
NIAID NIH HHS R01 AI084873NIAID NIH HHS R01-AI084873NIAID NIH HHS R01 AI093104NIAID NIH HHS R01-AI093104
6 · The paper itself

Abstract

The Lyme disease spirochetes, Borrelia burgdorferi (sensu lato), must cause persistent, disseminated infection to be maintained in the natural enzootic cycle. In human Lyme disease, spirochetes spread from the site of a tick bite to colonize multiple tissue sites, causing multisystem clinical manifestations. The Lyme spirochetes produce many adhesive surface proteins that collectively recognize diverse host substrates and cell types and are likely to promote dissemination and chronic infection in a variety of tissues. Recent application of state-of-the-art in vivo imaging technologies is illuminating mechanisms of interaction of B. burgdorferi with the host and the importance of multiple adhesins during mammalian infection.

Indexed as

Bacterial AdhesionHost-Pathogen InteractionsAdhesins, BacterialAnimalsBorrelia burgdorferi GroupHumansMicroscopyOptical ImagingAdhesins, BacterialadhesinsBorrelia burgdorferidisseminationintravital imagingLyme diseasetransmigration

Identifiers

PMID23876218
PMCPMC3773214
OpenAlexW2085991602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.