ArticleBreast cancer research : BCR2013
Change of mammographic density predicts the risk of contralateral breast cancer--a case-control study.
Article in Breast cancer research : BCR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review.The Cochrane database of systematic reviews · 2021Pooled it
- The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study.Breast cancer research : BCR · 2018Trial
- Measuring mammographic density: comparing a fully automated volumetric assessment versus European radiologists' qualitative classification.European radiology · 2016Trial
- Area and volumetric density estimation in processed full-field digital mammograms for risk assessment of breast cancer.PloS one · 2014Trial
- Evaluating mammographic density polygenic risk score for contralateral breast cancer risk prediction.Scientific reports · 2026Article
- Change in mammographic density as a potential predictor of cancer recurrence after breast conservation surgery and adjuvant endocrine therapy: results of the MEDICI study.Breast cancer research : BCR · 2026Article
- Assessing breast density using the chemical-shift encoding-based proton density fat fraction in 3-T MRI.European radiology · 2023Article
- Mammographic density in relation to breast cancer recurrence and survival in women receiving neoadjuvant chemotherapy.Frontiers in oncology · 2023Article
- Impact of systemic adjuvant therapy and CYP2D6 activity on mammographic density in a cohort of tamoxifen-treated breast cancer patients.Breast cancer research and treatment · 2021Article
- Mammographic texture features associated with contralateral breast cancer in the WECARE Study.NPJ breast cancer · 2021Article
- Biological Mechanisms and Therapeutic Opportunities in Mammographic Density and Breast Cancer Risk.Cancers · 2021Review
- Mammography features for early markers of aggressive breast cancer subtypes and tumor characteristics: A population-based cohort study.International journal of cancer · 2021Article
- Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden.Breast (Edinburgh, Scotland) · 2020Article
- Mammographic density change in a cohort of premenopausal women receiving tamoxifen for breast cancer prevention over 5 years.Breast cancer research : BCR · 2020Article
- Effect of neoadjuvant chemotherapy on breast tissue composition: a longitudinal mammographic study with automated volumetric measurement.European radiology · 2020Article
- Mammographic Density Change and Risk of Breast Cancer.Journal of the National Cancer Institute · 2020Article
- Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer.BMC cancer · 2019Article
- A review of the influence of mammographic density on breast cancer clinical and pathological phenotype.Breast cancer research and treatment · 2019Review
- Diffuse optical tomography of the breast: a potential modifiable biomarker of breast cancer risk with neoadjuvant chemotherapy.Biomedical optics express · 2019Article
- Mammographic density changes following discontinuation of tamoxifen in premenopausal women with oestrogen receptor-positive breast cancer.European radiology · 2018Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionMammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).
methodsWe collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.
resultsPatients who experienced ≥10% absolute decrease in percent density had a 55% decreased odds of CBC (OR = 0.45 95% CI: 0.24 to 0.84) relative to patients who had little or no change in density from baseline to first follow-up mammogram (mean = 1.6 (SD = 0.6) years after diagnosis), whereas among those who experienced an absolute increase in percent density we could not detect any effect on the odds of CBC (OR = 0.83 95% CI: 0.24 to 2.87).
conclusionDecrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment.
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