Trial reportEpilepsia2013
Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsy.
Trial report in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01463033 (Pilot), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Use of antiepileptic drugs as prophylaxis against posttraumatic seizures in the pediatric population: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta-analysis.Epilepsia · 2022Pooled it
- Pharmacological treatments for preventing epilepsy following traumatic head injury.The Cochrane database of systematic reviews · 2015Pooled it
- Article
- The normative modelling framework for traumatic brain injury.Brain : a journal of neurology · 2025Review
- Effect of levetiracetam and valproate on late-onset post-traumatic seizures.Acta epileptologica · 2023Article
- Scoping review of disease-modifying effect of drugs in experimental epilepsy.Frontiers in neurology · 2023Article
- Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.International journal of molecular sciences · 2022Article
- Regulation of Inflammation-Related Genes throughInternational journal of molecular sciences · 2022Article
- Civilian gunshot wounds to the head: a case report, clinical management, and literature review.Chinese neurosurgical journal · 2021Article
- Early Post-traumatic Seizure Occurrence in Pediatric Patients Receiving Levetiracetam Prophylaxis With Severe Traumatic Brain Injury.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Effect of epileptiform abnormality burden on neurologic outcome and antiepileptic drug management after subarachnoid hemorrhage.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- Predictors of post-discharge seizures in children with traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Management of post-traumatic epilepsy: An evidence review over the last 5 years and future directions.Epilepsia open · 2017Article
- Review
- The New Antiepileptic Drugs: Their Neuropharmacology and Clinical Indications.Neurologia medico-chirurgica · 2016Review
- Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms.Behavioural neurology · 2016Review
- Long-Term Consequences of Traumatic Brain Injury: Current Status of Potential Mechanisms of Injury and Neurological Outcomes.Journal of neurotrauma · 2015Review
- Pediatric head injury: a pain for the emergency physician?Clinical and experimental emergency medicine · 2015Review
- The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Posttraumatic seizures develop in up to 20% of children following severe traumatic brain injury (TBI). Children ages 6-17 years with one or more risk factors for the development of posttraumatic epilepsy, including presence of intracranial hemorrhage, depressed skull fracture, penetrating injury, or occurrence of posttraumatic seizure were recruited into this phase II study. Treatment subjects received levetiracetam 55 mg/kg/day, b.i.d., for 30 days, starting within 8 h postinjury. The recruitment goal was 20 treated patients. Twenty patients who presented within 8-24 h post-TBI and otherwise met eligibility criteria were recruited for observation. Follow-up was for 2 years. Forty-five patients screened within 8 h of head injury met eligibility criteria and 20 were recruited into the treatment arm. The most common risk factor present for pediatric inclusion following TBI was an immediate seizure. Medication compliance was 95%. No patients died; 19 of 20 treatment patients were retained and one observation patient was lost to follow-up. The most common severe adverse events in treatment subjects were headache, fatigue, drowsiness, and irritability. There was no higher incidence of infection, mood changes, or behavior problems among treatment subjects compared to observation subjects. Only 1 (2.5%) of 40 subjects developed posttraumatic epilepsy (defined as seizures >7 days after trauma). This study demonstrates the feasibility of a pediatric posttraumatic epilepsy prevention study in an at-risk traumatic brain injury population. Levetiracetam was safe and well tolerated in this population. This study sets the stage for implementation of a prospective study to prevent posttraumatic epilepsy in an at-risk population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.