ArticleACS nano2013
Stretching and controlled motion of single-stranded DNA in locally heated solid-state nanopores.
Article in ACS nano, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Review
- Review
- Localized Nanopore Fabrication via Controlled Breakdown.Nanomaterials (Basel, Switzerland) · 2022Review
- Label-Free Optical Analysis of Biomolecules in Solid-State Nanopores: Toward Single-Molecule Protein Sequencing.ACS photonics · 2022Review
- Ionic heat dissipation in solid-state pores.Science advances · 2022Article
- Multi-resolution simulation of DNA transport through large synthetic nanostructures.Physical chemistry chemical physics : PCCP · 2022Review
- Conformational Changes of Immobilized Polythymine due to External Stressors Studied with Temperature-Controlled Electrochemical Microdevices.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Scalable molecular dynamics on CPU and GPU architectures with NAMD.The Journal of chemical physics · 2020Article
- Colloquium: Ionic phenomena in nanoscale pores through 2D materials.Reviews of modern physics · 2019Article
- Review
- Conic shapes have higher sensitivity than cylindrical ones in nanopore DNA sequencing.Scientific reports · 2018Article
- Nanopore Sensing of Protein Folding.ACS nano · 2017Article
- Graphene Nanopores for Protein Sequencing.Advanced functional materials · 2016Article
- Molecular Dynamics Simulation of DNA Capture and Transport in Heated Nanopores.ACS applied materials & interfaces · 2016Article
- Nanoscale dynamics of Joule heating and bubble nucleation in a solid-state nanopore.Physical review. E · 2016Article
- Intrinsic Stepwise Translocation of Stretched ssDNA in Graphene Nanopores.Nano letters · 2015Article
- Article
- Ionic conductivity, structural deformation, and programmable anisotropy of DNA origami in electric field.ACS nano · 2015Article
- DNA translocations through solid-state plasmonic nanopores.Nano letters · 2014Article
- Modeling thermophoretic effects in solid-state nanopores.Journal of computational electronics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Practical applications of solid-state nanopores for DNA detection and sequencing require the electrophoretic motion of DNA through the nanopores to be precisely controlled. Controlling the motion of single-stranded DNA presents a particular challenge, in part because of the multitude of conformations that a DNA strand can adopt in a nanopore. Through continuum, coarse-grained and atomistic modeling, we demonstrate that local heating of the nanopore volume can be used to alter the electrophoretic mobility and conformation of single-stranded DNA. In the nanopore systems considered, the temperature near the nanopore is modulated via a nanometer-size heater element that can be radiatively switched on and off. The local enhancement of temperature produces considerable stretching of the DNA fragment confined within the nanopore. Such stretching is reversible, so that the conformation of DNA can be toggled between compact (local heating is off) and extended (local heating is on) states. The effective thermophoretic force acting on single-stranded DNA in the vicinity of the nanopore is found to be sufficiently large (4-8 pN) to affect such changes in the DNA conformation. The local heating of the nanopore volume is observed to promote single-file translocation of DNA strands at transmembrane biases as low as 10 mV, which opens new avenues for using solid-state nanopores for detection and sequencing of DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.