ArticleJournal of neurogastroenterology and motility2013
Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea.
Article in Journal of neurogastroenterology and motility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Risk factors and 26-years worldwide prevalence of endoscopic erosive esophagitis from 1997 to 2022: a meta-analysis.Scientific reports · 2023Pooled it
- Prevalence and impact of sleep disorders in patients with hereditary angioedema: A multicenter cross-sectional study in Latin America.Sleep & breathing = Schlaf & Atmung · 2026Article
- Article
- Gender-Specific Association Between Erosive Esophagitis and Sleep Disturbance: Do Mild Lesions Matter in Men?Gut and liver · 2026Article
- Article
- Article
- Association of depression with gastroesophageal reflux disease, and the mediating role of risk factors: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Impact of negative emotions on upper gastrointestinal diseases: A Mendel randomization study.PloS one · 2024Article
- The association between symptoms of gastroesophageal reflux disease and perceived stress: A countrywide study of Sri Lanka.PloS one · 2023Article
- Sex and Gender Differences in Overlap Syndrome of Functional Gastrointestinal Disorder and Effect of Genetic Polymorphisms in South Korea: A Long-term Follow-up Study.Journal of neurogastroenterology and motility · 2022Article
- The Influence of Gastroesophageal Reflux Disease on Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea.Journal of neurogastroenterology and motility · 2021Article
- Reflux Esophagitis and Fatigue: Are They Related?Journal of clinical medicine · 2021Article
- Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex.Journal of neurogastroenterology and motility · 2020Article
- Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study.Journal of neurogastroenterology and motility · 2018Article
- Comparison of Tight Junction Protein-Related Gene mRNA Expression Levels between Male and Female Gastroesophageal Reflux Disease Patients.Gut and liver · 2018Article
- Article
- The Role of Microbiome in Insomnia, Circadian Disturbance and Depression.Frontiers in psychiatry · 2018Review
- Gender differences in ghrelin, nociception genes, psychological factors and quality of life in functional dyspepsia.World journal of gastroenterology · 2017Article
- Association Between Excessive Daytime Sleepiness and Functional Gastrointestinal Disorders: A Population-based Study in China.Journal of neurogastroenterology and motility · 2017Article
- Sex and Gender Differences in Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2016Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsSleep disturbances and emotional dysfunction are commonly associated with gastroeophageal reflux disease (GERD). The aims of this study were to evaluate GERD symptoms and disturbance in erosive reflux disease (ERD) and nonerosive reflux disease (NERD) patients, and to compare sleep dysfunction, depressive mood, anxiety and quality of life (QOL) among the control, ERD and NERD patients in Korea.
methodsThe Korean subjects were enrolled between 2010 and 2012, classified into 3 groups; the control group with no symptom and normal endoscopic findings, the ERD group with erosive esophagitis and the NERD group with more than one episode of heartburn or acid regurgitation per week, positive response to proton pump inhibitor, and normal endoscopic findings. Questionnaire included GERD symptoms, GERD impact scale (GIS) and daytime pathological sleepiness (Epworth sleepiness scale), sleep dysfunction (Pittsburgh sleep quality index, PSQI), depression and anxiety (Hospital anxiety and depression scale, HADS) and QOL (WHO quality of life scale abbreviated version, WHOQOL-BREF).
resultsA total of 217 subjects were enrolled as follows; control (n = 70), ERD (n = 70) and NERD (n = 77). Impact of symptom of GIS score was higher in the NERD (9.2 ± 0.4) than in the ERD (6.5 ± 0.3) group (P < 0.001). Sleep dysfunctions were more frequent in GERD than the control group (PSQI score [P = 0.021]). Anxiety subscale of HAD score was higher in NERD (7.0 ± 0.5, P = 0.002) and ERD (6.2 ± 0.7, P = 0.004) groups than control (4.3 ± 0.7) group. WHOQOL-BREF scores in NERD (54.9 ± 2.3) and ERD (57.8 ± 2.4) groups were significantly lower than those in the control group (63.8 ± 2.4) (P = 0.002; P = 0.014, respectively).
conclusionsThe patients with NERD than ERD suffered more from the symptoms and disturbance in Korea. Sleep dysfunction and anxiety mood were higher and QOL was decreased in GERD, especially in NERD, suggesting that those factors might affect the severity of NERD.
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