ArticlePloS one2013
Cluster J mycobacteriophages: intron splicing in capsid and tail genes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
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- Nuclease genes occupy boundaries of genetic exchange between bacteriophages.bioRxiv : the preprint server for biology · 2023Article
- Complete Genome Sequences of Mycobacteriophages Dallas and Jonghyun.Microbiology resource announcements · 2021Article
- Phage Therapy for Mycobacterium Abscessus and Strategies to Improve Outcomes.Microorganisms · 2021Review
- Actinobacteriophages: Genomics, Dynamics, and Applications.Annual review of virology · 2020Review
- Isolation and Characterization ofAntibiotics (Basel, Switzerland) · 2020Article
- Complete Genome Sequences of Cluster G Mycobacteriophage Darionha, Cluster A Mycobacteriophage Salz, and Cluster J Mycobacteriophage ThreeRngTarjay.Microbiology resource announcements · 2020Article
- Mycobacteriophages.Microbiology spectrum · 2018Review
- Complete Genome Sequence of Cluster J Mycobacteriophage Superphikiman.Genome announcements · 2018Article
- Expression and evolutionary patterns of mycobacteriophage D29 and its temperate close relatives.BMC microbiology · 2017Article
- A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization.Current biology : CB · 2017Article
- Genome Sequences of Gordonia terrae Phages Attis and SoilAssassin.Genome announcements · 2016Article
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- Genome-based identification of active prophage regions by next generation sequencing in Bacillus licheniformis DSM13.PloS one · 2015Article
- Molecular Genetics of Mycobacteriophages.Microbiology spectrum · 2014Article
- Cluster M mycobacteriophages Bongo, PegLeg, and Rey with unusually large repertoires of tRNA isotypes.Journal of virology · 2014Article
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Authors and funding
18 authors at 6 institutions in 1 country.
Funding
Abstract
Bacteriophages isolated on Mycobacterium smegmatis mc(2)155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function. A new group of genomes sharing substantial nucleotide sequences constitute Cluster J. The six mycobacteriophages forming Cluster J are morphologically members of the Siphoviridae, but have unusually long genomes ranging from 106.3 to 117 kbp. Reconstruction of the capsid by cryo-electron microscopy of mycobacteriophage BAKA reveals an icosahedral structure with a triangulation number of 13. All six phages are temperate and homoimmune, and prophage establishment involves integration into a tRNA-Leu gene not previously identified as a mycobacterial attB site for phage integration. The Cluster J genomes provide two examples of intron splicing within the virion structural genes, one in a major capsid subunit gene, and one in a tail gene. These genomes also contain numerous free-standing HNH homing endonuclease, and comparative analysis reveals how these could contribute to genome mosaicism. The unusual Cluster J genomes provide new insights into phage genome architecture, gene function, capsid structure, gene mobility, intron splicing, and evolution.
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