ArticlePloS one2013
Venous thromboembolism in an industrial north american city: temporal distribution and association with particulate matter air pollution.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Air pollution and venous thrombosis: a meta-analysis.Scientific reports · 2016Pooled it
- Long-term exposure to air pollution and the risks of venous thromboembolism: a nationwide population-based retrospective cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Risk of venous thromboembolism associated with short-term exposure to fine particulate matter (PMResearch and practice in thrombosis and haemostasis · 2025Article
- Imperatives and co-benefits of research into climate change and neurological disease.Nature reviews. Neurology · 2025Review
- Season of delivery and risk of venous thromboembolism during hospitalization among pregnant women.Frontiers in public health · 2023Article
- Correlation of Air Pollution and Prevalence of Acute Pulmonary Embolism in Northern Thailand.International journal of environmental research and public health · 2022Article
- Effects of Short-Term Air Pollution Exposure on Venous Thromboembolism: A Case-Crossover Study.Annals of the American Thoracic Society · 2021Article
- Seasonal association between ambient fine particulate matter and venous thromboembolism in Beijing, China: a time-series study.Environmental science and pollution research international · 2021Article
- Effect of alcohol intoxication on the risk of venous thromboembolism: A nationwide retrospective cohort study.Medicine · 2017Article
- Acute Effects of Particulate Air Pollution on Ischemic Heart Disease Hospitalizations in Shanghai, China.International journal of environmental research and public health · 2017Article
- Spatial and temporal variations of satellite-derived multi-year particulate data of Saudi Arabia: an exploratory analysis.International journal of environmental research and public health · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging evidence, mainly from Europe and Asia, indicates that venous thromboembolism (VTE) occurs most often in winter. Factors implicated in such seasonality are low temperature-mediated exacerbation of coagulation and high levels of particulate matter (PM) air pollution. However, in contrast to most European and Asian cities, particulate matter pollution peaks in the summer in many North American cities.
objectivesWe aimed to exploit this geographical difference and examine the temporal distribution of VTE in a cold-weather, North American city, Detroit, with a summer PM peak. Our goal was thereby to resolve the influence of temperature and PM levels on VTE.
methodsOur retrospective, analytical semi-ecological study used chart review to confirm 1,907 acute, ambulatory VTE cases, divided them by location (Detroit versus suburban), and plotted monthly VTE frequency distributions. We used Environmental Protection Agency data to determine the temporal distribution of PM pollution components in Detroit. Suburban PM air pollution is presumed negligible and therefore not monitored.
resultsAcute VTE cases in Detroit (1,490) exhibited a summer peak (June 24(th)) and differed from both a uniform distribution (P<0.01) and also that of 1,123 no-VTE cases (P<0.02). Levels of 10 µm diameter PM and coarse particle (2.5 to 10 µm) PM also exhibited summer peaks versus a winter peak for 2.5 µm diameter PM. Contrary to their urban counterparts, suburban cases of acute VTE (417) showed no monthly variation.
conclusionsThe summer peak of acute VTE in Detroit indicates that low temperature is not a major factor in VTE pathogenesis. In contrast, concordance of the 10 µm diameter PM, coarse particle, and the Detroit VTE monthly distributions, combined with no monthly suburban VTE variation, is consistent with a role for PM pollution. Furthermore, divergence of the VTE and 2.5 µm PM distributions suggests that particle size may play a role.
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