ArticlePloS one2013
Characterization of virulence properties in the C. parapsilosis sensu lato species.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 80 citations in OpenAlex.
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- Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events.G3 (Bethesda, Md.) · 2022Article
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- The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes.Virulence · 2021Article
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- Virulence of ClinicalPathogens (Basel, Switzerland) · 2021Article
- Identification and Characterization of a Neutral Locus for Knock-in Purposes inFrontiers in microbiology · 2020Article
- In vitro characterization of virulence factors among species of the Candida parapsilosis complex.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
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- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- Echinocandin-Induced Microevolution of Candida parapsilosis Influences Virulence and Abiotic Stress Tolerance.mSphere · 2018Article
- Phenotype-driven strategies for screening Candida parapsilosis complex for molecular identification.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2018Article
- Pathogenesis of the Candida parapsilosis Complex in the Model Host Caenorhabditis elegans.Genes · 2018Article
- Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction.Scientific reports · 2018Article
- Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens.Journal of biomedical science · 2017Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The C. parapsilosis sensu lato group involves three closely related species, C. parapsilosis sensu stricto, C. orthopsilosis and C. metapsilosis. Although their overall clinical importance is dramatically increasing, there are few studies regarding the virulence properties of the species of the psilosis complex. In this study, we tested 63 C. parapsilosis sensu stricto, 12 C. metapsilosis and 18 C. orthopsilosis isolates for the ability to produce extracellular proteases, secrete lipases and form pseudohyphae. Significant differences were noted between species, with the C. metapsilosis strains failing to secrete lipase or to produce pseudohyphae. Nine different clinical isolates each of C. parapsilosis sensu stricto, C. orthopsilosis and C. metapsilosis were co-cultured with immortalized murine or primary human macrophages. C. parapsilosis sensu stricto isolates showed a significantly higher resistance to killing by primary human macrophages compared to C. orthopsilosis and C. metapsilosis isolates. In contrast, the killing of isolates by J774.2 mouse macrophages did not differ significantly between species. However, C. parapsilosis sensu stricto isolates induced the most damage to murine and human macrophages, and C. metapsilosis strains were the least toxic. Furthermore, strains that produced lipase or pseudohyphae were most resistant to macrophage-mediated killing and produced the most cellular damage. Finally, we used 9 isolates of each of the C. parapsilosis sensus lato species to examine their impact on the survival of Galleriamellonella larvae. The mortality rate of G. mellonella larvae infected with C. metapsilosis isolates was significantly lower than those infected with C. parapsilosis sensu stricto or C. orthopsilosis strains. Taken together, our findings demonstrate that C. metapsilosis is indeed the least virulent member of the psilosis group, and also highlight the importance of pseudohyphae and secreted lipases during fungal-host interactions.
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