ArticlePloS one2013
The loudness dependence of auditory evoked potentials (LDAEP) as an indicator of serotonergic dysfunction in patients with predominant schizophrenic negative symptoms.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
- Microbiome composition and central serotonergic activity in patients with depression and type 1 diabetes.European archives of psychiatry and clinical neuroscience · 2024Article
- Electroconvulsive therapy modulates loudness dependence of auditory evoked potentials: a pilot MEG study.Frontiers in psychiatry · 2024Article
- Acoustic and Subjective Basis of Emotional Perception in Comatose Patients: A Comparative Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Association between Cortical GABA and Loudness Dependence of Auditory Evoked Potentials (LDAEP) in Humans.The international journal of neuropsychopharmacology · 2018Article
- GABA metabolism and its role in gamma-band oscillatory activity during auditory processing: An MRS and EEG study.Human brain mapping · 2017Article
- Serotonergic modulation of orbitofrontal activity and its relevance for decision making and impulsivity.Human brain mapping · 2017Article
- Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice.Journal of psychiatry & neuroscience : JPN · 2017Article
- Estimation of Symptom Severity Scores for Patients with Schizophrenia Using ERP Source Activations during a Facial Affect Discrimination Task.Frontiers in neuroscience · 2017Article
- Article
- Tobacco use is associated with reduced amplitude and intensity dependence of the cortical auditory evoked N1-P2 component.Psychopharmacology · 2016Article
- A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings.International journal of endocrinology · 2015Review
- Influence of the 5-HT3A Receptor Gene Polymorphism and Childhood Sexual Trauma on Central Serotonin Activity.PloS one · 2015Article
- Early Recognition of High Risk of Bipolar Disorder and Psychosis: An Overview of the ZInEP "Early Recognition" Study.Frontiers in public health · 2014Article
- Cortical response variation with different sound pressure levels: a combined event-related potentials and FMRI study.PloS one · 2014Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Besides the influence of dopaminergic neurotransmission on negative symptoms in schizophrenia, there is evidence that alterations of serotonin (5-HT) system functioning also play a crucial role in the pathophysiology of these disabling symptoms. From post mortem and genetic studies on patients with negative symptoms a 5-HT dysfunction is documented. In addition atypical neuroleptics and some antidepressants improve negative symptoms via serotonergic action. So far no research has been done to directly clarify the association between the serotonergic functioning and the extent of negative symptoms. Therefore, we examined the status of brain 5-HT level in negative symptoms in schizophrenia by means of the loudness dependence of auditory evoked potentials (LDAEP). The LDAEP provides a well established and non-invasive in vivo marker of the central 5-HT activity. We investigated 13 patients with schizophrenia with predominant negative symptoms treated with atypical neuroleptics and 13 healthy age and gender matched controls with a 32-channel EEG. The LDAEP of the N1/P2 component was evaluated by dipole source analysis and single electrode estimation at Cz. Psychopathological parameters, nicotine use and medication were assessed to control for additional influencing factors. Schizophrenic patients showed significantly higher LDAEP in both hemispheres than controls. Furthermore, the LDAEP in the right hemisphere in patients was related to higher scores in scales assessing negative symptoms. A relationship with positive symptoms was not found. These data might suggest a diminished central serotonergic neurotransmission in patients with predominant negative symptoms.
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