ArticlePloS one2013
Magnetic resonance imaging interpretation in patients with sciatica who are potential candidates for lumbar disc surgery.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03924791 (Transforaminal Epidural Injection in Acute Sciatica), which is not on this map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transforaminal Epidural Injection in Acute Sciatica
Who cites it
8 citing papers in PubMed.
- Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica.British journal of clinical pharmacology · 2016Trial
- Clinical Utility of AI-Enabled CT-to-MRI Translation for Degenerative Spinal Disorders: A Retrospective Reader Study.Diagnostics (Basel, Switzerland) · 2026Article
- Comparison of magnetic resonance imaging findings among sciatica patients classified as centralizers or non-centralizers.The Journal of manual & manipulative therapy · 2023Article
- The Essence of Clinical Practice Guidelines for Lumbar Disc Herniation, 2021: 3. Diagnosis.Spine surgery and related research · 2022Article
- Article
- Lumbar disc extrusions reduce faster than bulging discs due to an active role of macrophages in sciatica.Acta neurochirurgica · 2020Observational
- Disc inflammation and Modic changes show an interaction effect on recovery after surgery for lumbar disc herniation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
- A diagnostic study in patients with sciatica establishing the importance of localization of worsening of pain during coughing, sneezing and straining to assess nerve root compression on MRI.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMagnetic Resonance Imaging (MRI) is considered the mainstay imaging investigation in patients suspected of lumbar disc herniations. Both imaging and clinical findings determine the final decision of surgery. The objective of this study was to assess MRI observer variation in patients with sciatica who are potential candidates for lumbar disc surgery.
methodsPatients for this study were potential candidates (n = 395) for lumbar disc surgery who underwent MRI to assess eligibility for a randomized trial. Two neuroradiologists and one neurosurgeon independently evaluated all MRIs. A four point scale was used for both probability of disc herniation and root compression, ranging from definitely present to definitely absent. Multiple characteristics of the degenerated disc herniation were scored. For inter-agreement analysis absolute agreements and kappa coefficients were used. Kappa coefficients were categorized as poor (<0.00), slight (0.00-0.20), fair (0.21-0.40), moderate (0.41-0.60), substantial (0.61-0.80) and excellent (0.81-1.00) agreement.
resultsExcellent agreement was found on the affected disc level (kappa range 0.81-0.86) and the nerve root that most likely caused the sciatic symptoms (kappa range 0.86-0.89). Interobserver agreement was moderate to substantial for the probability of disc herniation (kappa range 0.57-0.77) and the probability of nerve root compression (kappa range 0.42-0.69). Absolute pairwise agreement among the readers ranged from 90-94% regarding the question whether the probability of disc herniation on MRI was above or below 50%. Generally, moderate agreement was observed regarding the characteristics of the symptomatic disc level and of the herniated disc.
conclusionThe observer variation of MRI interpretation in potential candidates for lumbar disc surgery is satisfactory regarding characteristics most important in decision for surgery. However, there is considerable variation between observers in specific characteristics of the symptomatic disc level and herniated disc.
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