ArticlePloS one2013
A superfamily of DNA transposons targeting multicopy small RNA genes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- A megatransposon drives the adaptation of Thermoanaerobacter kivui to carbon monoxide.Nature communications · 2025Article
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- A unique eukaryotic lineage of composite-like DNA transposons encoding a DDD/E transposase and a His-Me finger homing endonuclease.Mobile DNA · 2022Article
- Diversity and Evolution of DNA Transposons Targeting Multicopy Small RNA Genes from Actinopterygian Fish.Biology · 2022Article
- Epigenetic silencing of clustered tRNA genes in Arabidopsis.Nucleic acids research · 2020Article
- Whole Genome Sequence of an Edible and Potential Medicinal Fungus,G3 (Bethesda, Md.) · 2018Article
- Cut-and-Paste Transposons in Fungi with Diverse Lifestyles.Genome biology and evolution · 2017Article
- Distribution of the DNA transposon family, Pokey in the Daphnia pulex species complex.Mobile DNA · 2016Article
- Molecular organization and comparative analysis of chromosome 5B of the wild wheat ancestor Triticum dicoccoides.Scientific reports · 2015Article
- Article
- Ancient Origin of the U2 Small Nuclear RNA Gene-Targeting Non-LTR Retrotransposons Utopia.PloS one · 2015Article
- Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons.Human gene therapy methods · 2014Article
- Virus world as an evolutionary network of viruses and capsidless selfish elements.Microbiology and molecular biology reviews : MMBR · 2014Review
- Casposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity.BMC biology · 2014Article
- The Wide Distribution and Change of Target Specificity of R2 Non-LTR Retrotransposons in Animals.PloS oneArticle
- Retroviral Integrase Structure and DNA Recombination Mechanism.Microbiology spectrumArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Target-specific integration of transposable elements for multicopy genes, such as ribosomal RNA and small nuclear RNA (snRNA) genes, is of great interest because of the relatively harmless nature, stable inheritance and possible application for targeted gene delivery of target-specific transposable elements. To date, such strict target specificity has been observed only among non-LTR retrotransposons. We here report a new superfamily of sequence-specific DNA transposons, designated Dada. Dada encodes a DDE-type transposase that shows a distant similarity to transposases encoded by eukaryotic MuDR, hAT, P and Kolobok transposons, as well as the prokaryotic IS256 insertion element. Dada generates 6-7 bp target site duplications upon insertion. One family of Dada DNA transposons targets a specific site inside the U6 snRNA genes and are found in various fish species, water flea, oyster and polycheate worm. Other target sequences of the Dada transposons are U1 snRNA genes and different tRNA genes. The targets are well conserved in multicopy genes, indicating that copy number and sequence conservation are the primary constraints on the target choice of Dada transposons. Dada also opens a new frontier for target-specific gene delivery application.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.