ArticlePloS one2013
Headcase promotes cell survival and niche maintenance in the Drosophila testis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster.PLoS genetics · 2024Article
- Article
- The adult Drosophila testis lacks a mechanism to replenish missing niche cells.Development (Cambridge, England) · 2023Article
- Mutation inFrontiers in cell and developmental biology · 2022Article
- Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.Developmental cell · 2021Article
- Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells.PLoS genetics · 2021Article
- Epigenetic Modifications May Regulate the Activation of the Hypopharyngeal Gland of Honeybees (Frontiers in genetics · 2020Article
- Article
- Article
- YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells.PloS one · 2019Article
- microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis.The Journal of cell biology · 2018Article
- Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge.Developmental biology · 2017Article
- Apontic regulates somatic stem cell numbers in Drosophila testes.BMC developmental biology · 2016Article
- Article
- Genetics of gonadal stem cell renewal.Annual review of cell and developmental biology · 2015Review
- Investigating spermatogenesis in Drosophila melanogaster.Methods (San Diego, Calif.) · 2014Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
At the apical tip of the Drosophila testis, germline and somatic stem cells surround a cluster of somatic cells called the hub. Hub cells produce a self-renewal factor, Unpaired (Upd), that activates the JAK-STAT pathway in adjacent stem cells to regulate stem cell behavior. Therefore, apical hub cells are a critical component of the stem cell niche in the testis. In the course of a screen to identify factors involved in regulating hub maintenance, we identified headcase (hdc). Hub cells depleted for hdc undergo programmed cell death, suggesting that anti-apoptotic pathways play an important role in maintenance of the niche. Using hdc as paradigm, we describe here the first comprehensive analysis on the effects of a progressive niche reduction on the testis stem cell pool. Surprisingly, single hub cells remain capable of supporting numerous stem cells, indicating that although the size and number of niche support cells influence stem cell maintenance, the testis stem cell niche appears to be remarkably robust in the its ability to support stem cells after severe damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.