ArticlePloS one2013
Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 79 citations in OpenAlex.
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- Brain histamine and oleoylethanolamide restore behavioral deficits induced by chronic social defeat stress in mice.Neurobiology of stress · 2021Article
- Synthesis, Quantification, and Characterization of Fatty Acid Amides from In Vitro and In Vivo Sources.Molecules (Basel, Switzerland) · 2021Review
- Genetic Manipulation of sn-1-Diacylglycerol Lipase and CBCannabis and cannabinoid research · 2021Article
- Cannabinoids modulate food preference and consumption in Drosophila melanogaster.Scientific reports · 2021Article
- Plasma endocannabinoids and cannabimimetic fatty acid derivatives are altered in gastroparesis: A sex- and subtype-dependent observation.Neurogastroenterology and motility · 2021Article
- The Biosynthesis and Metabolism of theFrontiers in molecular biosciences · 2021Review
- Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats.Psychopharmacology · 2020Article
- Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster.Cell reports · 2020Article
- Tissue-specific analysis of lipid species inJournal of lipid research · 2020Article
- Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression.Frontiers in molecular biosciences · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Lipid metabolism is critical to coordinate organ development and physiology in response to tissue-autonomous signals and environmental cues. Changes to the availability and signaling of lipid mediators can limit competitiveness, adaptation to environmental stressors, and augment pathological processes. Two classes of lipids, the N-acyl amides and the 2-acyl glycerols, have emerged as important signaling molecules in a wide range of species with important signaling properties, though most of what is known about their cellular functions is from mammalian models. Therefore, expanding available knowledge on the repertoire of these lipids in invertebrates will provide additional avenues of research aimed at elucidating biosynthetic, metabolic, and signaling properties of these molecules. Drosophila melanogaster is a commonly used organism to study intercellular communication, including the functions of bioactive lipids. However, limited information is available on the molecular identity of lipids with putative biological activities in Drosophila. Here, we used a targeted lipidomics approach to identify putative signaling lipids in third instar Drosophila larvae, possessing particularly large lipid mass in their fat body. We identified 2-linoleoyl glycerol, 2-oleoyl glycerol, and 45 N-acyl amides in larval tissues, and validated our findings by the comparative analysis of Oregon-RS, Canton-S and w1118 strains. Data here suggest that Drosophila represent another model system to use for the study of 2-acyl glycerol and N-acyl amide signaling.
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