ArticlePloS one2013
A functional promoter polymorphism of IFITM3 is associated with susceptibility to pediatric tuberculosis in Han Chinese population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Interferon-induced transmembrane proteins: membrane gatekeepers of fusion and infection.Frontiers in cellular and infection microbiology · 2026Review
- Peptidomic changes in human serous colorectal cancer patients.Journal of gastrointestinal oncology · 2023Article
- Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes.Nature communications · 2021Article
- Infectivity and Progression of COVID-19 Based on Selected Host Candidate Gene Variants.Frontiers in genetics · 2020Article
- IFITM3 promotes bone metastasis of prostate cancer cells by mediating activation of the TGF-β signaling pathway.Cell death & disease · 2019Article
- Population genetics of IFITM3 in Portugal and Central Africa reveals a potential modifier of influenza severity.Immunogenetics · 2018Article
- The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection.Frontiers in immunology · 2018Article
- IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral Infections.Frontiers in microbiology · 2018Review
- SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans.Nature medicine · 2017Article
- Evaluation of interferon-induced transmembrane protein-3 (Biomedical reports · 2016Article
- Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity.EMBO reports · 2016Article
- A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection.Cell reports · 2015Article
- A 3'UTR polymorphism of IL-6R is associated with Chinese pediatric tuberculosis.BioMed research international · 2014Article
- Genetic contribution of CISH promoter polymorphisms to susceptibility to tuberculosis in Chinese children.PloS one · 2014Article
- IFITMs restrict the replication of multiple pathogenic viruses.Journal of molecular biology · 2013Review
- Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A susceptibility locus for tuberculosis, a re-emerging infectious disease throughout the world, was previously discovered to exist on chromosome 11p15. IFITM3 gene encoding for interferon inducible transmembrane protein 3, is located at 11p15. It acts as an effector molecule for interferon-gamma, which is essential for anti-tuberculosis immune response. In order to investigate the association between susceptibility to TB and genetic polymorphisms of the IFITM3 core promoter, a case-control study including 368 TB patients and 794 healthy controls was performed in Han Chinese children in northern China. The rs3888188 polymorphism showed significant association with susceptibility to TB. The rs3888188 G allele, acting recessively, was more frequent in TB patients (95% confidence interval: 1.08-1.56, Bonferroni P-value: 0.039). We further assessed the effect of rs3888188 polymorphism on IFITM3 transcription in vitro. As based on luciferase promoter assays, the promoter activity of haplotypes with rs3888188 G allele was lower than that of haplotypes with rs3888188 T allele. Moreover, peripheral-blood mononuclear cells carrying rs3888188 GG genotype showed a reduced IFITM3 mRNA level compared to cells carrying TT or GT genotype. In conclusion, rs3888188, a functional promoter polymorphism of IFITM3, was identified to influence the risk for pediatric TB in Han Chinese population.
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