ArticleFrontiers in microbiology2013
Do antibiotic residues in soils play a role in amplification and transmission of antibiotic resistant bacteria in cattle populations?
Article in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Population-level mathematical modeling of antimicrobial resistance: a systematic review.BMC medicine · 2019Pooled it
- A Peek into the Relationship Between Probiotic Characteristics of Lactiplantibacillus plantarum Strains and Sortase A Gene Expression.Current microbiology · 2025Article
- Assessing the impact of biosecurity compliance on farmworker and livestock health within a one health modeling framework.One health (Amsterdam, Netherlands) · 2025Article
- Human and Veterinary Medicine Collaboration: Synergistic Approach to Address Antimicrobial Resistance Through the Lens of Planetary Health.Antibiotics (Basel, Switzerland) · 2025Review
- The Role of the Environment in Dynamics of Antibiotic Resistance in Humans and Animals: A Modelling Study.Antibiotics (Basel, Switzerland) · 2022Article
- Antibiotic resistant bacteria: A bibliometric review of literature.Frontiers in public health · 2022Review
- Genome of Bifidobacterium longum NCIM 5672 provides insights into its acid-tolerance mechanism and probiotic properties.Archives of microbiology · 2021Article
- Antibiotics and Antibiotic Resistance Genes in Animal Manure - Consequences of Its Application in Agriculture.Frontiers in microbiology · 2021Review
- Dairy farm soil presents distinct microbiota and varied prevalence of antibiotic resistance across housing areas.Environmental pollution (Barking, Essex : 1987) · 2019Article
- High Prevalence of Cefotaxime Resistant Bacteria in Grazing Beef Cattle: A Cross Sectional Study.Frontiers in microbiology · 2019Article
- Effects of treatment with enrofloxacin or tulathromycin on fecal microbiota composition and genetic function of dairy calves.PloS one · 2019Article
- Risk Factors for Detection, Survival, and Growth of Antibiotic-Resistant and Pathogenic Escherichia coli in Household Soils in Rural Bangladesh.Applied and environmental microbiology · 2018Article
- Effects of intramuscularly administered enrofloxacin on the susceptibility of commensal intestinal Escherichia coli in pigs (sus scrofa domestica).BMC veterinary research · 2017Article
- Models of antimicrobial pressure on intestinal bacteria of the treated host populations.Epidemiology and infection · 2017Article
- Monte Carlo Simulations Suggest Current Chlortetracycline Drug-Residue Based Withdrawal Periods Would Not Control Antimicrobial Resistance Dissemination from Feedlot to Slaughterhouse.Frontiers in microbiology · 2017Article
- Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators.Frontiers in microbiology · 2016Review
- Veterinary Medicine Needs New Green Antimicrobial Drugs.Frontiers in microbiology · 2016Review
- Recent Emergence of Escherichia coli with Cephalosporin Resistance Conferred by blaCTX-M on Washington State Dairy Farms.Applied and environmental microbiology · 2015Article
- Antibiotics in Canadian poultry productions and anticipated alternatives.Frontiers in microbiology · 2014Review
- Modelling dynamics of plasmid-gene mediated antimicrobial resistance in enteric bacteria using stochastic differential equations.Scientific reports · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When we consider factors that contribute to the emergence, amplification, and persistence of antibiotic resistant bacteria, the conventional assumption is that antibiotic use is the primary driver in these processes and that selection occurs primarily in the patient or animal. Evidence suggests that this may not always be the case. Experimental trials show that parenteral administration of a third-generation cephalosporin (ceftiofur) in cattle has limited or short-term effects on the prevalence of ceftiofur-resistant bacteria in the gastrointestinal tract. While this response may be sufficient to explain a pattern of widespread resistance to cephalosporins, approximately two-thirds of ceftiofur metabolites are excreted in the urine raising the possibility that environmental selection plays an important additive role in the amplification and maintenance of antibiotic resistant E. coli on farms. Consequently, we present a rationale for an environmental selection hypothesis whereby excreted antibiotic residues such as ceftiofur are a significant contributor to the proliferation of antibiotic resistant bacteria in food animal systems. We also present a mathematical model of our hypothesized system as a guide for designing experiments to test this hypothesis. If supported for antibiotics such as ceftiofur, then there may be new approaches to combat the proliferation of antibiotic resistance beyond the prudent use mantra.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.