ArticleFrontiers in physiology2013
The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?
Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Acute and Intermittent Exogenous Ketosis to Support Recovery From Exercise and Adaptations to Exercise Training: A Narrative Review.Scandinavian journal of medicine & science in sports · 2025Review
- Enduring effects of acute prenatal ischemia in rat soleus muscle, and protective role of erythropoietin.Journal of muscle research and cell motility · 2025Article
- Acute Sarcopenia: Mechanisms and Management.Nutrients · 2024Review
- Ketone monoester ingestion increases postexercise serum erythropoietin concentrations in healthy men.American journal of physiology. Endocrinology and metabolism · 2023Article
- The Role of Skeletal Muscle Mitochondria in Colorectal Cancer Related Cachexia: Friends or Foes?International journal of molecular sciences · 2022Review
- Nutrition and Exercise Treatment of Sarcopenia in Hip Fracture Patients: Systematic Review.Journal of bone metabolism · 2022Article
- Relation Between Gender and Concomitant Medications With Erythropoietin-Treatment on Wound Healing in Burn Patients. Post Hoc Subgroup-Analysis of the Randomized, Placebo-Controlled Clinical Trial "EPO in Burns".Frontiers in pharmacology · 2022Article
- Article
- The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise.Pflugers Archiv : European journal of physiology · 2021Article
- Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China.Frontiers in genetics · 2021Article
- Rehabilitation Strategies for Patients with Femoral Neck Fractures in Sarcopenia: A Narrative Review.Journal of clinical medicine · 2020Review
- Erythropoietin Alleviates Burn-induced Muscle Wasting.International journal of medical sciences · 2020Article
- Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia.Frontiers in physiology · 2020Review
- Intranasal Erythropoietin Protects CA1 Hippocampal Cells, Modulated by Specific Time Pattern Molecular Changes After Ischemic Damage in Rats.Journal of molecular neuroscience : MN · 2019Article
- What is the role of erythropoietin prolotherapy on pain relief of knee osteoarthritis?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Article
- Erythropoietin enhances Kupffer cell number and activity in the challenged liver.Scientific reports · 2017Article
- Erythropoietin enhances migration of human neuroblastoma cells: in vitro studies and potential therapeutic implications.Journal of cancer stem cell research · 2017Article
- Erythropoietin Reduces Insulin Resistance via Regulation of Its Receptor-Mediated Signaling Pathways inInternational journal of biological sciences · 2017Article
- IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.The Journal of biological chemistry · 2016Article
- Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice.Hypoxia (Auckland, N.Z.) · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythropoietin (EPO) primarily activates erythroid cell proliferation and growth and is active in several types of non-hematopoietic cells via its interaction with the EPO-receptor (EPO-R). This review focuses on the role of EPO in skeletal muscle. The EPO-R is expressed in skeletal muscle cells and EPO may promote myoblast differentiation and survival via the activation of the same signaling cascades as in hematopoietic cells, such as STAT5, MAPK and Akt. Inconsistent results exist with respect to the detection of the EPO-R mRNA and protein in muscle cells, tissue and across species and the use of non-specific EPO-R antibodies contributes to this problem. Additionally, the inability to reproducibly detect an activation of the known EPO-induced signaling pathways in skeletal muscle questions the functionality of the EPO-R in muscle in vivo. These equivocal findings make it difficult to distinguish between a direct effect of EPO on skeletal muscle, via the activation of its receptor, and an indirect effect resulting from a better oxygen supply to the muscle. Consequently, the precise role of EPO in skeletal muscle and its regulatory mechanism/s remain to be elucidated. Further studies are required to comprehensively establish the importance of EPO and its function in skeletal muscle health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.