ArticleFrontiers in integrative neuroscience2013
Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia.
Article in Frontiers in integrative neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
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- Novel Combination of Choline withInternational journal of molecular sciences · 2023Article
- Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins.Biology · 2023Article
- Stressed Microglia: Neuroendocrine-Neuroimmune Interactions in the Stress Response.Endocrinology · 2023Review
- Prolactin Attenuates Neuroinflammation in LPS-Activated SIM-A9 Microglial Cells by Inhibiting NF-κB Pathways Via ERK1/2.Cellular and molecular neurobiology · 2022Article
- Microglia involvement in sex-dependent behaviors and schizophrenia occurrence in offspring with maternal dexamethasone exposure.Schizophrenia (Heidelberg, Germany) · 2022Article
- Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice.Journal of neuroinflammation · 2022Article
- Low-Density Lipoprotein Cholesterol Is a Possible Blood Biomarker of Schizoid Personality Traits among Females.Journal of personalized medicine · 2022Article
- The Properties and Functions of Glial Cell Types of the Hypothalamic Median Eminence.Frontiers in endocrinology · 2022Review
- Behavioral, neurochemical, and neuroimmune changes associated with social buffering and stress contagion.Neurobiology of stress · 2022Article
- Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia.Endocrinology · 2021Review
- Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network.Pharmaceuticals (Basel, Switzerland) · 2021Review
- The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations.Translational psychiatry · 2020Article
- Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits.Nature genetics · 2019Article
- Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia.Molecular neurobiology · 2019Article
- Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies.Frontiers in cellular neuroscience · 2019Article
- Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.Scientific reports · 2018Article
- Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer's Disease Pathogenesis.Frontiers in neuroscience · 2017Review
- Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder.Frontiers in immunology · 2016Article
- Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw.Neurochemical research · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocrine systems have long been suggested to be one of the important factors in neuropsychiatric disorders, while the underlying mechanisms have not been well understood. Traditionally, neuropsychiatric disorders have been mainly considered the consequence of abnormal conditions in neural circuitry. Beyond the neuronal doctrine, microglia, one of the glial cells with inflammatory/immunological functions in the central nervous system (CNS), have recently been suggested to play important roles in neuropsychiatric disorders. However, the crosstalk between neuroendocrine factors, neuropsychiatric disorders, and microglia has been unsolved. Therefore, we herein introduce and discuss a missing and possible link between these three factors; especially highlighting the following hormones; (1) Hypothalamic-Pituitary-Adrenal (HPA) axis-related hormones such as corticotropin-releasing hormone (CRH) and glucocorticoids, (2) sex-related hormones such as estrogen and progesterone, and (3) oxytocin. A growing body of evidence has suggested that these hormones have a direct effect on microglia. We hypothesize that hormone-induced microglial activation and the following microglia-derived mediators may lead to maladaptive neuronal networks including synaptic dysfunctions, causing neuropsychiatric disorders. Future investigations to clarify the correlation between neuroendocrine factors and microglia may contribute to a novel understanding of the pathophysiology of neuropsychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.