ArticlePLoS computational biology2013
A model for the self-organization of vesicular flux and protein distributions in the Golgi apparatus.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- Theoretical approaches for understanding the self-organized formation of the Golgi apparatus.Development, growth & differentiation · 2023Review
- Article
- Golgi apparatus self-organizes into the characteristic shape via postmitotic reassembly dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Nonequilibrium description of de novo biogenesis and transport through Golgi-like cisternae.Scientific reports · 2016Article
- Article
- Wine glasses and hourglasses: Non-adaptive complexity of vesicle traffic in microbial eukaryotes.Molecular and biochemical parasitologyArticle
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2 authors.
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Abstract
The generation of two non-identical membrane compartments via exchange of vesicles is considered to require two types of vesicles specified by distinct cytosolic coats that selectively recruit cargo, and two membrane-bound SNARE pairs that specify fusion and differ in their affinities for each type of vesicles. The mammalian Golgi complex is composed of 6-8 non-identical cisternae that undergo gradual maturation and replacement yet features only two SNARE pairs. We present a model that explains how distinct composition of Golgi cisternae can be generated with two and even a single SNARE pair and one vesicle coat. A decay of active SNARE concentration in aging cisternae provides the seed for a cis[Formula: see text]trans SNARE gradient that generates the predominantly retrograde vesicle flux which further enhances the gradient. This flux in turn yields the observed inhomogeneous steady-state distribution of Golgi enzymes, which compete with each other and with the SNAREs for incorporation into transport vesicles. We show analytically that the steady state SNARE concentration decays exponentially with the cisterna number. Numerical solutions of rate equations reproduce the experimentally observed SNARE gradients, overlapping enzyme peaks in cis, medial and trans and the reported change in vesicle nature across the Golgi: Vesicles originating from younger cisternae mostly contain Golgi enzymes and SNAREs enriched in these cisternae and extensively recycle through the Endoplasmic Reticulum (ER), while the other subpopulation of vesicles contains Golgi proteins prevalent in older cisternae and hardly reaches the ER.
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