Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2013
A randomized phase II clinical trial of high-dose nicotine patch therapy for smokeless tobacco users.
Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00939029 (Highdose Nicotine Patch Therapy for Smokeless Tobacco Use), which is not on this map. Cited by 7 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Highdose Nicotine Patch Therapy for Smokeless Tobacco Use
Who cites it
7 citing papers in PubMed, 4 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Efficacy of pharmacological intervention for smokeless tobacco cessation in adults: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2025Pooled it
- Interventions for smokeless tobacco use cessation.The Cochrane database of systematic reviews · 2025Pooled it
- Smokeless tobacco cessation interventions: A systematic review.The Indian journal of medical research · 2018Pooled it
- Interventions for smokeless tobacco use cessation.The Cochrane database of systematic reviews · 2015Pooled it
- The effectiveness of nicotine replacement therapy on oral smokeless tobacco cessation and reduction rate: A systematic review.Tobacco prevention & cessation · 2025Review
- Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use.Frontiers in cardiovascular medicine · 2023Review
- The effect of oral uptake of nicotine in snus on peripheral skin blood circulation evaluated by thermography.Temperature (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionNicotine patch therapy has not been shown to be efficacious for increasing long-term (≥6 months) tobacco abstinence rates among smokeless tobacco (ST) users. Higher doses of nicotine patch therapy may be needed to increase tobacco abstinence rates in this population of tobacco users.
methodsWe randomized ST users who used ≥3 cans/pouches per week to either 8 weeks of high-dose nicotine patch therapy (42mg/day) or matching placebo patch. Subjects were followed for 6 months after randomization.
resultsFifty-two subjects were randomized. Compared with placebo, high-dose nicotine patch therapy was associated with significantly higher prolonged tobacco abstinence at end-of-treatment (44% vs. 22%, odds ratio [OR] = 2.7, p = .050) and 3 months (40% vs. 19%, OR = 2.9, p = .047). High-dose nicotine patch therapy was associated with significant weight gain attenuation among tobacco abstinence subjects at 3 months (p = .013) and 6 months (p = .018). Compared with placebo, high-dose nicotine patch therapy was associated with nonsignificantly lower nicotine withdrawal scores. Adverse events were not significantly increased with high-dose nicotine patch therapy.
conclusionsHigh-dose nicotine patch therapy is safe and increases short-term tobacco abstinence rates among ST users who use ≥3 cans/pouches per week. High-dose nicotine patch therapy is associated with significant long-term attenuation of weight gain. Future studies to investigate the long-term efficacy of high-dose nicotine patch therapy and the comparative efficacy of this approach compared with standard nicotine patch doses for ST users seems warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.