ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies.Traffic (Copenhagen, Denmark) · 2026Review
- GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.Endocrinology · 2019Article
- Article
- Growth Hormone's Effect on Adipose Tissue: Quality versus Quantity.International journal of molecular sciences · 2017Review
- Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action.Endocrinology · 2017Article
- Inability to replete white adipose tissue during recovery phase of sepsis is associated with increased autophagy, apoptosis, and proteasome activity.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.Clinical proteomics · 2017Review
- Association study between growth hormone receptor (Journal of exercise rehabilitation · 2016Article
- Context Specific and Differential Gene Co-expression Networks via Bayesian Biclustering.PLoS computational biology · 2016Article
- Altered somatotroph feedback regulation improves metabolic efficiency and limits adipose deposition in male mice.Metabolism: clinical and experimental · 2016Article
- Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.Oncotarget · 2015Article
- GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells.The Journal of endocrinology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Growth hormone receptor-null (GHR(-/-)) mice are dwarf, insulin sensitive, and long-lived in spite of increased adiposity. However, their adiposity is not uniform, with select white adipose tissue (WAT) depots enlarged. To study WAT depot-specific effects on insulin sensitivity and life span, we analyzed individual WAT depots of 12- and 24-month-old GHR(-) (/-) and wild-type (WT) mice, as well as their plasma levels of selected hormones. Adipocyte sizes and plasma insulin, leptin, and adiponectin levels decreased with age in both GHR(-) (/-) and WT mice. Two-dimensional gel electrophoresis proteomes of WAT depots were similar among groups, but several proteins involved in endocytosis and/or cytoskeletal organization (Ehd2, S100A10, actin), anticoagulation (S100A10, annexin A5), and age-related conditions (alpha2-macroglobulin, apolipoprotein A-I, transthyretin) showed significant differences between genotypes. Because Ehd2 may regulate endocytosis of Glut4, we measured Glut4 levels in the WAT depots of GHR(-) (/-) and WT mice. Inguinal WAT of 12-month-old GHR(-) (/-) mice displayed lower levels of Glut4 than WT. Overall, the protein changes detected in this study offer new insights into possible mechanisms contributing to enhanced insulin sensitivity and extended life span in GHR(-) (/-) mice.
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Registered trials
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