ArticleGenes & development2013
Does the microenvironment influence the cell types of origin for prostate cancer?
Article in Genes & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Lineage plasticity and histological transformation: tumor histology as a spectrum.Cell research · 2025Review
- Novel insights in cell cycle dysregulation during prostate cancer progression.Endocrine-related cancer · 2021Review
- Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment.Cancers · 2021Article
- Its written all over your face: The molecular and physiological consequences of aging skin.Mechanisms of ageing and development · 2020Review
- Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.Molecular & cellular proteomics : MCP · 2019Article
- The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.Oncotarget · 2017Article
- v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1.Cancer research · 2016Article
- Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.Oncogene · 2016Article
- Current status and perspectives in atomic force microscopy-based identification of cellular transformation.International journal of nanomedicine · 2016Review
- The many ways to make a luminal cell and a prostate cancer cell.Endocrine-related cancer · 2015Review
- Advanced neuroendocrine prostate tumors regress to stemness.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Prostate cancer metastasis: roles of recruitment and reprogramming, cell signal network and three-dimensional growth characteristics.Translational andrology and urology · 2015Review
- Inflammation and prostate cancer: friends or foe?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Review
- Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways.Neoplasia (New York, N.Y.) · 2014Article
- Luminal cells are favored as the cell of origin for prostate cancer.Cell reports · 2014Article
- Cancer stem cells: constantly evolving and functionally heterogeneous therapeutic targets.Cancer research · 2014Article
- Inflammation promotes prostate differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Beyond the androgen receptor: new approaches to treating metastatic prostate cancer. Report of the 2013 Prouts Neck Prostate Cancer Meeting.The Prostate · 2014Article
- Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.Neoplasia (New York, N.Y.) · 2014Article
- Prostate epithelial stem and progenitor cells.American journal of clinical and experimental urology · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Despite several recent studies addressing the cells of origin for prostate cancer, there is still considerable discussion in the field regarding the most relevant target populations for transformation. Tissue regeneration studies have pointed to a basal cell origin for mouse and human prostate cancer. In contrast, genetically engineered mouse models demonstrate that cells within both the basal and luminal layers can initiate murine prostate cancer. Based on differences between these two approaches, we propose that further work should address the requirement for microenvironmental components such as immune or mesenchymal cells on epithelial cell types of origin for prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.