ArticleGenome biology and evolution2013
Comparison of metabolic capacities and inference of gene content evolution in mosquito-associated Spiroplasma diminutum and S. taiwanense.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
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- Integrated Information for Pathogenicity and Treatment of Spiroplasma.Current microbiology · 2024Review
- The evolution of abdominal microbiomes in fungus-growing ants.Molecular ecology · 2019Article
- Horizontal Gene Acquisitions Contributed to Genome Expansion in Insect-Symbiotic Spiroplasma clarkii.Genome biology and evolution · 2018Article
- Complete Genome Sequence of Spiroplasma monobiae MQ-1Genome announcements · 2018Article
- Complete Genome Sequence of Spiroplasma floricola 23-6Genome announcements · 2018Article
- Draft Genome Sequence ofGenome announcements · 2018Article
- Horizontal Acquisition and Transcriptional Integration of Novel Genes in Mosquito-Associated Spiroplasma.Genome biology and evolution · 2017Article
- Complete Genome Sequence ofGenome announcements · 2017Article
- Complete Genome Sequence of Spiroplasma sp. TU-14.Genome announcements · 2017Article
- Winding paths to simplicity: genome evolution in facultative insect symbionts.FEMS microbiology reviews · 2016Review
- Complete Genome Sequence of Spiroplasma helicoides TABS-2T (DSM 22551), a Bacterium Isolated from a Horsefly (Tabanus abactor).Genome announcements · 2016Article
- Complete Genome Sequence of Spiroplasma turonicum Tab4cT, a Bacterium Isolated from Horse Flies (Haematopota sp.).Genome announcements · 2016Article
- Complete Genome Sequence of Spiroplasma cantharicola CC-1T (DSM 21588), a Bacterium Isolated from Soldier Beetle (Cantharis carolinus).Genome announcements · 2015Article
- Complete Genome Sequence of Spiroplasma litorale TN-1T (DSM 21781), a Bacterium Isolated from a Green-Eyed Horsefly (Tabanus nigrovittatus).Genome announcements · 2015Article
- Found and Lost: The Fates of Horizontally Acquired Genes in Arthropod-Symbiotic Spiroplasma.Genome biology and evolution · 2015Article
- Complete Genome Sequence of Agrobacterium tumefaciens Ach5.Genome announcements · 2015Article
- Genome sequence of the Drosophila melanogaster male-killing Spiroplasma strain MSRO endosymbiont.mBio · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mosquitoes are hosts of several Spiroplasma species that belong to different serogroups. To investigate the genetic mechanisms that may be involved in the utilization of similar hosts in these phylogenetically distinct bacteria, we determined the complete genome sequences of Spiroplasma diminutum and S. taiwanense for comparative analysis. The genome alignment indicates that their chromosomal organization is highly conserved, which is in sharp contrast to the elevated genome instabilities observed in other Spiroplasma lineages. Examination of the substrate utilization strategies revealed that S. diminutum can use a wide range of carbohydrates, suggesting that it is well suited to living in the gut (and possibly the circulatory system) of its mosquito hosts. In comparison, S. taiwanense has lost several carbohydrate utilization genes and acquired additional sets of oligopeptide transporter genes through tandem duplications, suggesting that proteins from digested blood meal or lysed host cells may be an important nutrient source. Moreover, one glycerol-3-phosphate oxidase gene (glpO) was found in S. taiwanense but not S. diminutum. This gene is linked to the production of reactive oxygen species and has been shown to be a major virulence factor in Mycoplasma mycoides. This finding may explain the pathogenicity of S. taiwanense observed in previous artificial infection experiments, while no apparent effect was found for S. diminutum. To infer the gene content evolution at deeper divergence levels, we incorporated other Mollicutes genomes for comparative analyses. The results suggest that the losses of biosynthetic pathways are a recurrent theme in these host-associated bacteria.
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