ArticleJournal of bacteriology2013
RflM functions as a transcriptional repressor in the autogenous control of the Salmonella Flagellar master operon flhDC.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Structure of the proton-powered secretion motor at the heart of the bacterial flagellum.bioRxiv : the preprint server for biology · 2026Article
- Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway.Cell host & microbe · 2024Article
- Article
- Molecular structure of the intact bacterial flagellar basal body.Nature microbiology · 2021Article
- A mathematical model of flagellar gene regulation and construction in Salmonella enterica.PLoS computational biology · 2020Article
- Two Tandem Mechanisms Control Bimodal Expression of the Flagellar Genes in Salmonella enterica.Journal of bacteriology · 2020Article
- A LuxR-type regulator, AcrR, regulates flagellar assembly and contributes to virulence, motility, biofilm formation, and growth ability of Acidovorax citrulli.Molecular plant pathology · 2020Article
- Multidrug Resistance Regulators MarA, SoxS, Rob, and RamA Repress Flagellar Gene Expression and Motility in Salmonella enterica Serovar Typhimurium.Journal of bacteriology · 2019Article
- A Family of Small Intrinsically Disordered Proteins Involved in Flagellum-Dependent Motility in Salmonella enterica.Journal of bacteriology · 2019Article
- Article
- Article
- The master regulator of IncA/C plasmids is recognized by the Salmonella Genomic island SGI1 as a signal for excision and conjugal transfer.Nucleic acids research · 2015Article
- Flagellin Is Required for Host Cell Invasion and Normal Salmonella Pathogenicity Island 1 Expression by Salmonella enterica Serovar Paratyphi A.Infection and immunity · 2015Article
- Characterization of Novel Factors Involved in Swimming and Swarming Motility in Salmonella enterica Serovar Typhimurium.PloS one · 2015Article
- Regulatory principles governing Salmonella and Yersinia virulence.Frontiers in microbiology · 2015Review
- Mutually repressing repressor functions and multi-layered cellular heterogeneity regulate the bistable Salmonella fliC census.Molecular microbiology · 2014Article
- Comparative analysis of the secretion capability of early and late flagellar type III secretion substrates.Molecular microbiology · 2014Article
- The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC.Journal of bacteriology · 2014Article
- The effect of cell growth phase on the regulatory cross-talk between flagellar and Spi1 virulence gene expression.PLoS pathogens · 2014Article
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3 authors.
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Abstract
Motility of bacteria like Salmonella enterica is a highly regulated process that responds to a variety of internal and external stimuli. A hierarchy of three promoter classes characterizes the Salmonella flagellar system, and the onset of flagellar gene expression depends on the oligomeric regulatory complex and class 1 gene product FlhD(4)C(2). The flhDC promoter is a target for a broad range of transcriptional regulators that bind within the flhDC promoter region and either negatively or positively regulate flhDC operon transcription. In this work, we demonstrate that the RflM protein is a key component of flhDC regulation. Transposon mutagenesis was performed to investigate a previously described autoinhibitory effect of the flagellar master regulatory complex FlhD(4)C(2). RflM is a LuxR homolog that functions as a flagellar class 1 transcriptional repressor. RflM was found to be the negative regulator of flhDC expression that is responsible for the formerly described autoinhibitory effect of the FlhD(4)C(2) complex on flhDC operon transcription (K. Kutsukake, Mol. Gen. Genet. 254:440-448, 1997). We conclude that upon commencement of flagellar gene expression, the FlhD(4)C(2) complex initiates a regulatory feedback loop by activating rflM gene expression. rflM encodes a transcriptional repressor, RflM, which fine-tunes flhDC expression levels.
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