ArticleJournal of bacteriology2013
Identification and characterization of Clostridium sordellii toxin gene regulator.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- FatalPathogens (Basel, Switzerland) · 2025Review
- A Critical Review of Postbiotics as Promising Novel Therapeutic Agents for Clostridial Infections.Probiotics and antimicrobial proteins · 2025Review
- Role of glycogen metabolism inmSphere · 2024Article
- A Clostridioides difficile endolysin modulates toxin secretion without cell lysis.Communications biology · 2024Article
- Review
- A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL inToxins · 2022Article
- Prevalence and Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2021Article
- Large Clostridial Toxins: Mechanisms and Roles in Disease.Microbiology and molecular biology reviews : MMBR · 2021Review
- Virulence Plasmids of the Pathogenic Clostridia.Microbiology spectrum · 2019Article
- Enterotoxic Clostridia:Microbiology spectrum · 2019Review
- Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract.PLoS pathogens · 2018Article
- Article
- Review
- Comparative transcriptomics and proteomics of three different aphid species identifies core and diverse effector sets.BMC genomics · 2016Article
- Importance of Glutamate Dehydrogenase (GDH) in Clostridium difficile Colonization In Vivo.PloS one · 2016Article
- Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus.Scientific reports · 2015Article
- Comparative genomic and phenomic analysis of Clostridium difficile and Clostridium sordellii, two related pathogens with differing host tissue preference.BMC genomics · 2015Article
- Clostridium sordellii genome analysis reveals plasmid localized toxin genes encoded within pathogenicity loci.BMC genomics · 2015Article
- Integration of metabolism and virulence in Clostridium difficile.Research in microbiology · 2015Review
- Foot infection by Clostridium sordellii: case report and review of 15 cases in France.Journal of clinical microbiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Toxigenic Clostridium sordellii causes uncommon but highly lethal infections in humans and animals. Recently, an increased incidence of C. sordellii infections has been reported in women undergoing obstetric interventions. Pathogenic strains of C. sordellii produce numerous virulence factors, including sordellilysin, phospholipase, neuraminidase, and two large clostridial glucosylating toxins, TcsL and TcsH. Recent studies have demonstrated that TcsL toxin is an essential virulence factor for the pathogenicity of C. sordellii. In this study, we identified and characterized TcsR as the toxin gene (tcsL) regulator in C. sordellii. High-throughput sequencing of two C. sordellii strains revealed that tcsR lies within a genomic region that encodes TcsL, TcsH, and TcsE, a putative holin. By using ClosTron technology, we inactivated the tcsR gene in strain ATCC 9714. Toxin production and tcsL transcription were decreased in the tcsR mutant strain. However, the complemented tcsR mutant produced large amounts of toxins, similar to the parental strain. Expression of the Clostridium difficile toxin gene regulator tcdR also restored toxin production to the C. sordellii tcsR mutant, showing that these sigma factors are functionally interchangeable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.