ArticleThe British journal of radiology2013
MDCT features in the differentiation of T4a gastric cancer from less-advanced gastric cancer: significance of the hyperattenuating serosa sign.
Article in The British journal of radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Trial
- Evaluation of gastric cancer using artificial intelligence iterative reconstruction on abdominal CT: image quality and diagnostic accuracy.Abdominal radiology (New York) · 2026Article
- Radiomics analysis of multiphase contrast-enhanced CT imaging for differentiating primary gastric lymphoma and Borrmann type IV gastric cancer.European journal of radiology open · 2026Article
- Preoperative prediction of serosal invasion in gastric cancer using multiphase contrast-enhanced CT radiomics.Frontiers in oncology · 2026Article
- Laparoscopic versus open distal gastrectomy with d2 lymphadenectomy in treatment of locally T4A gastric cancer: the protocol of a randomized controlled trial.BMC surgery · 2025Article
- Influence of visceral adipose tissue on the accuracy of tumor T-staging of gastric cancer in preoperative CT.Japanese journal of radiology · 2025Article
- Oncological risk of proximal gastrectomy for proximal advanced gastric cancer after neoadjuvant chemotherapy.BMC cancer · 2024Article
- The 'double‑track sign': A novel CT finding suggestive of the diagnosis of T1a gastric cancer.Oncology letters · 2023Article
- Added Value of the Sliding Sign on Right Down Decubitus CT for Determining Adjacent Organ Invasion in Patients with Advanced Gastric Cancer.Journal of the Korean Society of Radiology · 2022Article
- Diagnosis of Serosal Invasion in Gastric Adenocarcinoma by Dual-Energy CT Radiomics: Focusing on Localized Gastric Wall and Peritumoral Radiomics Features.Frontiers in oncology · 2022Article
- Article
- The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021.Cancer communications (London, England) · 2021Article
- Preoperative Staging of Gastric Cancer Using Computed Tomography and Its Correlation with Histopathology with Emphasis on Multi-planar Reformations and Virtual Gastroscopy.Journal of gastrointestinal cancer · 2021Observational
- A Transfer Learning Radiomics Nomogram for Preoperative Prediction of Borrmann Type IV Gastric Cancer From Primary Gastric Lymphoma.Frontiers in oncology · 2021Article
- Potential Value of Radiomics in the Identification of Stage T3 and T4a Esophagogastric Junction Adenocarcinoma Based on Contrast-Enhanced CT Images.Frontiers in oncology · 2021Article
- Computed Tomography-Based Radiomics Nomogram: Potential to Predict Local Recurrence of Gastric Cancer After Radical Resection.Frontiers in oncology · 2021Article
- Establishment of the Radiologic Tumor Invasion Index Based on Radiomics Splenic Features and Clinical Factors to Predict Serous Invasion of Gastric Cancer.Frontiers in oncology · 2021Article
- The Performance of a Dual-Energy CT Derived Radiomics Model in Differentiating Serosal Invasion for Advanced Gastric Cancer Patients After Neoadjuvant Chemotherapy: Iodine Map Combined With 120-kV Equivalent Mixed Images.Frontiers in oncology · 2020Article
- Usefulness of histologic differences and perivascular infiltration for preoperative T staging of advanced gastric cancer using computed tomography.Japanese journal of radiology · 2019Article
- Feasibility of differentiating T3 from T4a gastric cancer in different Lauren classification by determining serosa invasion: Diagnostic performance of high enhanced serosa sign.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018Article
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Abstract
objectiveThe purpose of our study was to evaluate CT findings to differentiate between T4a and less advanced gastric cancers.
methodsThe institutional review board approved this study and waived informed consent. This study included 228 retrospectively identified patients with surgically confirmed gastric cancer (138 T1, 25 T2, 24 T3 and 41 T4a) and who had also undergone pre-operative CT scan. Transverse and multiplanar reconstruction scans were reviewed in consensus by two other blinded radiologists. The following CT findings that differentiate T4a from less advanced cancers were evaluated: nodular or an irregular outer layer of the gastric wall, haziness of the perigastric fat and a hyperattenuating serosa sign. The CT features of T4a and less advanced gastric cancers were compared by means of univariate and multivariate analyses.
resultsIn univariate analysis, nodular or an irregular outer layer of the gastric wall, haziness of the perigastric fat and the hyperattenuating serosa sign were significant in differentiation between T4a and less advanced gastric cancers. In addition, nodular or an irregular outer layer of the gastric wall and the hyperattenuating serosa sign were significant in differentiation between T3 and T4a. In multivariate logistic analysis, the hyperattenuating serosa sign was the most significant finding in differentiation between T3 and T4a (odds ratio, 4.210; 95% confidence intervals, 1.581-11.214; p=0.004).
conclusionThe hyperattenuating serosa sign may be a useful CT finding in differentiation between T4a and less-advanced gastric cancers. ADVANCES IN KNOWLEDGE: The hyperattenuating serosa sign is associated with gastric cancer with invading the serosa and can facilitate planning of the optimal pre-operative evaluation and treatment.
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