ArticleAmerican journal of physiology. Lung cellular and molecular physiology2013
Sustained inflation at birth did not protect preterm fetal sheep from lung injury.
Article in American journal of physiology. Lung cellular and molecular physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Improving Newborn Respiratory Outcomes With a Sustained Inflation: A Systematic Narrative Review of Factors Regulating Outcome in Animal and Clinical Studies.Frontiers in pediatrics · 2020Pooled it
- Sustained lung inflation in late preterm infants: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2016Trial
- Speed of lung inflation at birth influences the initiation of lung injury in preterm lambs.JCI insight · 2024Article
- Respiratory strategy at birth initiates distinct lung injury phenotypes in the preterm lamb lung.Respiratory research · 2022Article
- Individualized dynamic PEEP (dynPEEP) vs. positive pressure ventilation in delivery room management: A retrospective cohort study.Frontiers in pediatrics · 2022Article
- The orphan nuclear receptor Nr4a1 mediates perinatal neuroinflammation in a murine model of preterm labor.Cell death & disease · 2020Article
- Plasma proteomics reveals gestational age-specific responses to mechanical ventilation and identifies the mechanistic pathways that initiate preterm lung injury.Scientific reports · 2018Article
- Effects of budesonide and surfactant in preterm fetal sheep.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Article
- Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs.Pediatric research · 2017Article
- Looking ahead: where to next for animal models of bronchopulmonary dysplasia?Cell and tissue research · 2017Review
- Can the preterm lung recover from perinatal stress?Molecular and cellular pediatrics · 2016Review
- Brief mechanical ventilation causes differential epithelial repair along the airways of fetal, preterm lambs.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Optimizing lung aeration at birth using a sustained inflation and positive pressure ventilation in preterm rabbits.Pediatric research · 2016Article
- The interrelationship of recruitment maneuver at birth, antenatal steroids, and exogenous surfactant on compliance and oxygenation in preterm lambs.Pediatric research · 2016Article
- Selection of Reference Genes for Gene Expression Studies related to lung injury in a preterm lamb model.Scientific reports · 2016Article
- Distending Pressure Did Not Activate Acute Phase or Inflammatory Responses in the Airways and Lungs of Fetal, Preterm Lambs.PloS one · 2016Article
- Utility of large-animal models of BPD: chronically ventilated preterm lambs.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Understanding the Impact of Infection, Inflammation, and Their Persistence in the Pathogenesis of Bronchopulmonary Dysplasia.Frontiers in medicine · 2015Review
- Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Sustained lung inflations (SI) at birth may recruit functional residual capacity (FRC). Clinically, SI increase oxygenation and decrease need for intubation in preterm infants. We tested whether a SI to recruit FRC would decrease lung injury from subsequent ventilation of fetal, preterm lambs. The preterm fetus (128±1 day gestation) was exteriorized from the uterus, a tracheostomy was performed, and fetal lung fluid was removed. While maintaining placental circulation, fetuses were randomized to one of four 15-min interventions: 1) positive end-expiratory pressure (PEEP) 8 cmH2O (n=4), 2) 20 s SI to 50 cmH2O then PEEP 8 cmH2O (n=10), 3) mechanical ventilation at tidal volume (VT) 7 ml/kg (n=13), or 4) 20 s SI then ventilation at VT 7 ml/kg (n=13). Lambs were ventilated with 95% N2/5% CO2 and PEEP 8 cmH2O. Volume recruitment was measured during SI, and fetal tissues were collected after an additional 30 min on placental support. SI achieved a mean FRC recruitment of 15 ml/kg (range 8-27). Fifty percent of final FRC was achieved by 2 s, 65% by 5 s, and 90% by 15 s, demonstrating prolonged SI times are needed to recruit FRC. SI alone released acute-phase proteins into the fetal lung fluid and increased mRNA expression of proinflammatory cytokines and acute-phase response genes in the lung. Mechanical ventilation further increased all markers of lung injury. SI before ventilation, regardless of the volume of FRC recruited, did not alter the acute-phase and proinflammatory responses to mechanical ventilation at birth.
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