ArticleAmerican journal of physiology. Lung cellular and molecular physiology2013
Effect of unilateral diaphragmatic paralysis on postpneumonectomy lung growth.
Article in American journal of physiology. Lung cellular and molecular physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Diaphragm-Directed Strategies for Prolonged Air Leak Prevention After Lung Resection: A Narrative Review of the Residual Pleural Space Paradigm.Journal of clinical medicine · 2026Review
- Evaluation of ventilation at 10 °C as the optimal storage condition for donor lungs in a murine model.Scientific reports · 2026Article
- Evolving topological order in the postnatal visceral pleura.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion.PloS one · 2020Article
- Single-Cell Transcriptional Profiling of Cells Derived From Regenerating Alveolar Ducts.Frontiers in medicine · 2020Article
- The puzzling mechanism of compensatory lung growth.Stem cell investigation · 2018Article
- Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?The Journal of pediatrics · 2017Review
- Nuclear factor-kappa B influences early phase of compensatory lung growth after pneumonectomy in mice.Journal of biomedical science · 2017Article
- Alveolar septal patterning during compensatory lung growth: Part II the effect of parenchymal pressure gradients.Journal of theoretical biology · 2017Article
- Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth.PloS one · 2017Article
- Deformation-induced transitional myofibroblasts contribute to compensatory lung growth.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Remodeling of alveolar septa after murine pneumonectomy.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Localization and stretch-dependence of lung elastase activity in development and compensatory growth.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Mouse pneumonectomy model of compensatory lung growth.Journal of visualized experiments : JoVE · 2014Article
- The clinical use of regenerative therapy in COPD.International journal of chronic obstructive pulmonary disease · 2014Review
- Airway smooth muscle in airway reactivity and remodeling: what have we learned?American journal of physiology. Lung cellular and molecular physiology · 2013Review
- Mapping cyclic stretch in the postpneumonectomy murine lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Respiratory muscle-associated stretch has been implicated in normal lung development (fetal breathing movements) and postpneumonectomy lung growth. To test the hypothesis that mechanical stretch from diaphragmatic contraction contributes to lung growth, we performed left phrenic nerve transections (PNT) in mice with and without ipsilateral pneumonectomy. PNT was demonstrated by asymmetric costal margin excursion and confirmed at autopsy. In mice with two lungs, PNT was associated with a decrease in ipsilateral lung volume (P<0.05) and lung weight (P<0.05). After pneumonectomy, PNT was not associated with a change in activity level, measureable hypoxemia, or altered minute ventilation; however, microCT scanning demonstrated altered displacement and underinflation of the cardiac lobe within the first week after pneumonectomy. Coincident with the altered structural realignment, lung impedance measurements, fitted to the constant-phase model, demonstrated elevated airway resistance (P<0.05), but normal peripheral tissue resistance (P>0.05). Most important, PNT appeared to abrogate compensatory lung growth after pneumonectomy; the weight of the lobes of the right lung was significantly less than pneumonectomy alone (P<0.001) and indistinguishable from nonsurgical controls (P>0.05). We conclude that the cyclic stretch associated with diaphragmatic muscle contraction is a controlling factor in postpneumonectomy compensatory lung growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.