Evidence map›Paper›PMID 23873439›Full record

ReviewNucleus (Austin, Tex.)

The nuclear envelope LEM-domain protein emerin.

Jason M Berk, Kathryn E Tifft, Katherine L Wilson

Open access · goldAbstract readReview
In one paragraph

Review in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 174 citations in OpenAlex.

  1. Article
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  3. Article
  4. Resistance-based exercise restores muscle health in dialysis patients.Journal of muscle research and cell motility · 2026
    Article
  5. Article
  6. Article
  7. Review
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  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The role of inner nuclear membrane protein emerin in myogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  19. Pulsatile flow induces chromatin interaction with lamin-associated proteins to enrich H3K9 methylation in endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jason M BerkDepartment of Cell Biology; Johns Hopkins University School of Medicine; Baltimore, MD USA.
Kathryn E Tifft
Katherine L Wilson
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
REGULATION OF NUCLEAR ENVELOPE ASSEMBLY AND DISASSEMBLYR01GM048646 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WILSON, KATHERINE L · 1994 to 2012
$4.9M
NIGMS NIH HHS R01 GM048646NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease--is available. This review summarizes emerin and its emerging roles in nuclear "lamina" structure, chromatin tethering, gene regulation, mitosis, nuclear assembly, development, signaling and mechano-transduction. We also highlight many open questions, exploration of which will be critical to understand how this intriguing nuclear membrane protein and its "family" influence the genome.

Indexed as

AnimalsCell NucleusHumansMembrane ProteinsNuclear EnvelopeNuclear ProteinsemerinMembrane ProteinsNuclear Proteinsbarrier-to-autointegration factoremerinEmery-Dreifuss muscular dystrophyGAGE cancer-testis antigenlaminopathyLEM-domainNestor-Guillermo progerianuclear envelopenucleoskeletonO-GlcNAc transferase

Identifiers

PMID23873439
PMCPMC3810338
OpenAlexW2036559009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.