SynthesisClinical oral investigations2014
The effect of radiotherapy on dental hard tissue--a systematic review.
Synthesis in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 192 citations in OpenAlex.
- A randomized controlled trial comparing the effect of salivary substitute and fluoride varnish on radiation caries in irradiated head and neck cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Results of a randomized controlled phase III trial: efficacy of polyphenol-containing cystus® tea mouthwash solution for the reduction of mucositis in head and neck cancer patients undergoing external beam radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Trial
- Efficiency of desensitizing materials in xerostomic patients with head and neck cancer: a comparative clinical study.Clinical oral investigations · 2020Trial
- Impact of radiotherapy on the morphological and compositional structure of intra-radicular dentin.Brazilian dental journalTrial
- Improved oral health in head and neck cancer survivors (OHHNC study): a study protocol for a multicentre two-armed randomised controlled trial.BMC cancer · 2026Article
- Article
- Damage of irradiated teeth by ultrasonic scaling: an in vitro study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Impact of Radiotherapy on the Condition of the Oral Cavity in Patients with Head and Neck Cancer.Journal of clinical medicine · 2026Article
- Dose-Dependent Effects of Simulated Clinical Radiotherapy on the Structure and Properties of Root Dentine.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.BMC oral health · 2026Article
- Investigations of Effects of Radiotherapy, Sonic Activation and Root Canal Treatment on Fracture Resistance of Mandibular Anterior Teeth: An In Vitro Study.Journal of clinical medicine · 2026Article
- Head and Neck Radiotherapy and Dentomaxillofacial Diagnostic Imaging: Biological Interactions and Protective Approaches.Biomedicines · 2025Review
- Water Absorption and Solubility of Fluoride-Based Restorative Materials Exposed to Ionizing Radiation.Polymers · 2025Article
- Materials and effects of intraoral device technologies for complication protection in head and neck cancer radiotherapy: a scoping review.BMC oral health · 2025Article
- Impact of radiotherapy in chemical composition and mechanical properties of human cervical dentin: an in vitro study.Journal of applied oral science : revista FOB · 2025Article
- Review
- Article
- Effectiveness of self-etching bonding systems on dentin after radiotherapy: perspectives on microtensile and microshear bond strength.Clinical oral investigations · 2024Article
- Effect of ionizing radiation on the shear bond strength of two different adhesive systems in primary teeth. in-vitro study.BMC oral health · 2024Article
- Effect of ionizing radiation on the microstructure and physical properties of endodontic gutta-percha points.European oral research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDecay of teeth, erosion and disintegration of hard dental tissue are a clinically often seen side effect after radiotherapy for tumours in the head and neck region. To investigate if these side effects are due to structural changes in dental hard tissues, the current literature was searched. It can influence the quality of life gravely.
methodA systematic PubMed (Medline) search was done and of the 374 hits, 11 articles were included. During the reading of these articles, 10 additional useful references to other articles were retrieved. An extra search was done on "A.M. Kielbassa", a key writer in many articles on this subject. Four extra articles were found. So in total, 25 articles were analysed in this systematic review.
resultsTooth destruction occurs often and soon after irradiation. There is no difference between decay in irradiated and non-irradiated teeth. The locations and the progressiveness of the destruction are different in irradiated then in non-irradiated teeth. Several studies show changes in the structure and micro hardness of enamel, the dentinoenamel junction (DEJ) and dentin. The biomechanical properties are dramatically decreased. The odds of moderate/severe tooth damage increased with the irradiation dose.
conclusionIn conclusion the results of this systematic review show a great amount of changes and damages at all levels of the hard dental tissues, enamel, DEJ and dentin. These findings substantiate the idea that the formation of recurrent and atypical patterns of dental caries in irradiated teeth is, not only due to loss of saliva but a combination of both hyposalivation and the direct effects on hard dental tissue. The formation of atypical caries is furthermore increased due to poor oral hygiene, the increase of soft and carbohydrate-rich substance and changes of the bacterial micro flora and proteins. CLINICAL RELEVANCE: This article is written to understand more about the cause of destruction of teeth after radiotherapy. This way, a more adequate preventive and restorative treatment plan can be drawn up for an individual patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.