ReviewHistochemistry and cell biology2013
Regulation of Golgi signaling and trafficking by the KDEL receptor.
Review in Histochemistry and cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Differential impact of bisphenol S on human arterial endothelial cells from healthy and type-2 diabetic donors: a high-content imaging study.Histochemistry and cell biology · 2026Article
- Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer.Open biology · 2024Article
- Sorting of secretory proteins at theeLife · 2024Article
- Article
- Synergistic Cytotoxicity of a Toxin Targeting the Epidermal Growth Factor Receptor and the Glycosylated Triterpenoid SO1861 in Prostate Cancer.Journal of Cancer · 2023Article
- KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration.Genetics and molecular biology · 2023Article
- Selective Secretion of KDEL-Bearing Proteins: Mechanisms and Functions.Frontiers in cell and developmental biology · 2022Review
- KDELR2 knockdown synergizes with temozolomide to induce glioma cell apoptosis through the CHOP and JNK/p38 pathways.Translational cancer research · 2021Article
- Review
- The Secreted Protein C10orf118 Is a New Regulator of Hyaluronan Synthesis Involved in Tumour-Stroma Cross-Talk.Cancers · 2021Article
- IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion.Oncogene · 2020Article
- Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases.Frontiers in cell and developmental biology · 2020Review
- Expansion of the Transporter-Opsin-G protein-coupled receptor superfamily with five new protein families.PloS one · 2020Article
- Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALRFrontiers in cellular neuroscience · 2019Article
- Models of Intracellular Transport: Pros and Cons.Frontiers in cell and developmental biology · 2019Article
- A secreted Heat shock protein 90 of Trichomonas vaginalis.PLoS neglected tropical diseases · 2018Article
- Article
- The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family.Toxins · 2015Review
- Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity.Frontiers in oncology · 2015Review
- Pseudomonas Exotoxin A: optimized by evolution for effective killing.Frontiers in microbiology · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Intracellular membrane transport involves the well-coordinated engagement of a series of organelles and molecular machineries that ensure that proteins are delivered to their correct cellular locations according to their function. To maintain the homeostasis of the secretory system, the fluxes of membranes and protein across the transport compartments must be precisely balanced. This control should rely on a mechanism that senses the movement of the traffic and generates the required homeostatic response. Due to its central position in the secretory pathway and to the large amounts of signaling molecules associated with it, the Golgi complex represents the ideal candidate for this regulation. The generation of autonomous signaling by the Golgi complex in response to the arrival of cargo from the endoplasmic reticulum (ER) has been experimentally addressed only in recent years. These studies have revealed that cargo moving from the ER to the Golgi activates a series of signaling pathways, the functional significance of which appears to be to maintain the homeostasis of the Golgi complex and to activate Golgi trafficking according to internal demand. We have termed this regulatory mechanism the Golgi control system. A key player in this Golgi control system is the KDEL receptor, which has previously been shown to retrieve chaperones back to the endoplasmic reticulum and more recently to behave as a signaling receptor. Here, we discuss the particular role of KDEL receptor signaling in the regulation of important pathways involved in the maintenance of the homeostasis of the transport apparatus, and in particular, of the Golgi complex.
Indexed as
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23873287What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.