Evidence map›Paper›PMID 23873090›Full record

ReviewEuropean archives of psychiatry and clinical neuroscience2013

The effects of physical exercise in schizophrenia and affective disorders.

Berend Malchow, Daniela Reich-Erkelenz, Viola Oertel-Knöchel, Katriona Keller, Alkomiet Hasan, Andrea Schmitt, Thomas W Scheewe, Wiepke Cahn, René S Kahn, Peter Falkai

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in European archives of psychiatry and clinical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02716584 nacompletednot on this mapstarted 2016, after this paper: background citation

Physical Exercise Effects on Determinants of Social Integration in Schizophrenia

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2016 to 2018Enrolled53ConditionsSchizophreniaArmsPhysical exercise, Stretching exercise
NCT06338917 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Moderate-to-Vigorous Intensity Physical Activity as a Tool for Severe Mental Illness Recuperation Process: Study Protocol for a Pragmatic Controlled Clinical Trial (+moviMENT)

TypeinterventionalSponsorUniversity of Vic - Central University of CataloniaRan2024 to 2026Enrolled100ConditionsMental Health IssueArmsModerate-to-vigorous intensity physical activity program (+moviMENT)
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Exercise to treat psychopathology and other clinical outcomes in schizophrenia: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Berend MalchowDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nußbaumstraße 7, 80336, Munich, Germany. berend.malchow@med.uni-muenchen.de
Daniela Reich-Erkelenz
Viola Oertel-Knöchel
Katriona Keller
Alkomiet Hasan
Andrea Schmitt
Thomas W Scheewe
Wiepke Cahn
René S Kahn
Peter Falkai
Ludwig-Maximilians-Universität München · DEGoethe University Frankfurt · DEHeidelberg University · DEUniversity Medical Center Utrecht · NLUniversity of Göttingen · DEWindesheim University of Applied Sciences · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Affective and non-affective psychoses are severe and frequent psychiatric disorders. Amongst others, they not only have a profound impact on affected individuals through their symptomatology, but also regarding cognition, brain structure and function. Cognitive impairment influences patients' quality of life as well as their ability to work and being employed. While exercise therapy has been implemented in the treatment of psychiatric conditions since the days of Kraepelin and Bleuler, the underlying mechanisms have never been systematically studied. Since the early 1990s, studies emerged examining the effect of physical exercise in animal models, revealing stimulation of neurogenesis, synaptogenesis and neurotransmission. Based on that body of work, clinical studies have been carried out in both healthy humans and in patient populations. These studies differ with regard to homogenous study samples, sample size, type and duration of exercise, outcome variables and measurement techniques. Based on their review, we draw conclusions regarding recommendations for future research strategies showing that modern therapeutic approaches should include physical exercise as part of a multimodal intervention programme to improve psychopathology and cognitive symptoms in schizophrenia and affective disorders.

Indexed as

BrainExerciseHumansMood DisordersNeurogenesisNeuroimagingSchizophrenia

Identifiers

PMID23873090
OpenAlexW2052275405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.