ArticleNature biotechnology2013
Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching.
Article in Nature biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 220 papers.
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Who cites it
220 citing papers in PubMed.
- Harnessing microRNA regulatory networks for engineering climate resilience and nutritional enhancement in millets.Stress biology · 2026Review
- Characterization, evolution, and expression profiling of cotton DUF677 protein family and their potential role in drought and salt stress response.BMC plant biology · 2026Article
- Article
- Genome-Wide Identification, Expression Profiling, and microRNA397-Mediated Regulation of Laccase Genes inPlants (Basel, Switzerland) · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- Gallic Acid-Responsive microRNAs Reprogram Lignification During Drought Acclimation Process in Spearmint.Plant biotechnology journal · 2026Article
- Telomere-to-telomere genome assemblies and population resequencing of diploid and allotetraploid peanut varieties.Nature genetics · 2026Article
- Cu-miRNA-mediated redox homeostasis explains the differences in cold tolerance between AAA and ABB banana varieties.Journal of advanced research · 2026Article
- MicroRNA networks in rice seeds: unveiling key regulators of development, germination, and rice resilience under climate changes.Journal of experimental botany · 2026Review
- Small but big player: the important role of microRNAs in legume crops.Molecular genetics and genomics : MGG · 2026Review
- Genome-wide identification, classification and expression analysis of laccase family members in Solanum lycopersicum.BMC plant biology · 2026Article
- Small but big player: the important role of microRNAs in rice.Frontiers in plant science · 2026Review
- Analysis of Genetic Variation of Rice Straw Characteristics and Its Influence on Biomass.Plant direct · 2026Article
- Gene Editing of a Susceptibility LncRNA Enhances Broad-Spectrum Disease Resistance in Rice without Developmental Trade-Offs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Integrative analyses reveal Bna-miR397a-BnaLAC2 as a potential modulator of low-temperature adaptability in Brassica napus L.Plant biotechnology journal · 2025Article
- Noncoding RNAs as tools for advancing translational biology in plants.The Plant cell · 2025Review
- The Mediator subunit OsMED23 associates with the histone demethylase OsJMJ703 and the transcription factor OsWOX3A to control grain size and yield in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Polymerization of proanthocyanidins under the catalysis of miR397a-regulated laccases in Salvia miltiorrhiza and Populus trichocarpa.Nature communications · 2025Article
- Non-coding RNA-mediated regulation of seed endosperm development.Frontiers in plant science · 2025Review
160 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing grain yields is a major focus of crop breeders around the world. Here we report that overexpression of the rice microRNA (miRNA) OsmiR397, which is naturally highly expressed in young panicles and grains, enlarges grain size and promotes panicle branching, leading to an increase in overall grain yield of up to 25% in a field trial. To our knowledge, no previous report has shown a positive regulatory role of miRNA in the control of plant seed size and grain yield. We determined that OsmiR397 increases grain yield by downregulating its target, OsLAC, whose product is a laccase-like protein that we found to be involved in the sensitivity of plants to brassinosteroids. As miR397 is highly conserved across different species, our results suggest that manipulating miR397 may be useful for increasing grain yield not only in rice but also in other cereal crops.
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