ArticleOncogene2014
Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression.
Article in Oncogene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis.International journal of molecular sciences · 2026Review
- Tumor-suppressive functions of protein lysine methyltransferases.Experimental & molecular medicine · 2023Review
- Low expression of PRDM5 predicts poor prognosis of esophageal squamous cell carcinoma.BMC cancer · 2022Article
- Aldehyde Dehydrogenase 2 Family Member (ALDH2) Is a Therapeutic Index for Oxaliplatin Response on Colorectal Cancer Therapy with Dysfunction p53.BioMed research international · 2022Article
- Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis.Frontiers of medicine · 2021Review
- Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice.Nature communications · 2020Article
- Multifaceted Role of PRDM Proteins in Human Cancer.International journal of molecular sciences · 2020Review
- Overexpression of PRDM5 promotes acute myeloid leukemia cell proliferation and migration by activating the JNK pathway.Cancer medicine · 2019Article
- PRDM5 Expression and Essential Role After Acute Spinal Cord Injury in Adult Rat.Neurochemical research · 2016Article
- PRDM5 promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression.Cancer medicine · 2016Article
- MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma.BMC cancer · 2016Article
- Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors.Oncotarget · 2016Article
- A role for repressive complexes and H3K9 di-methylation in PRDM5-associated brittle cornea syndrome.Human molecular genetics · 2015Article
- Bruch's membrane abnormalities in PRDM5-related brittle cornea syndrome.Orphanet journal of rare diseases · 2015Article
- Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups.BMC cancer · 2015Article
- Emerging role of PR domain containing 5 (PRDM5) as a broad tumor suppressor in human cancers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- The Endocannabinoid Signaling System in the CNS: A Primer.International review of neurobiology · 2015Review
- Endocannabinoids, related compounds and their metabolic routes.Molecules (Basel, Switzerland) · 2014Review
- Genomic and proteomic analyses of Prdm5 reveal interactions with insulator binding proteins in embryonic stem cells.Molecular and cellular biology · 2013Article
- CTCF As an Example of DNA-Binding Transcription Factors Containing Clusters of C2H2-Type Zinc Fingers.Acta naturaeArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PRDM proteins are tissue-specific transcription factors often deregulated in diseases, particularly in cancer where different members have been found to act as oncogenes or tumor suppressors. PRDM5 is a poorly characterized member of the PRDM family for which several studies have reported a high frequency of promoter hypermethylation in cancer types of gastrointestinal origin. We report here the characterization of Prdm5 knockout mice in the context of intestinal carcinogenesis. We demonstrate that loss of Prdm5 increases the number of adenomas throughout the murine small intestine on an Apc(Min) background. By using the genome-wide ChIP-seq (chromatin immunoprecipitation (ChIP) followed by DNA sequencing) and transcriptome analyses we identify loci encoding proteins involved in metabolic processes as prominent PRDM5 targets and characterize monoacylglycerol lipase (Mgll) as a direct PRDM5 target in human colon cancer cells and in Prdm5 mutant mouse intestines. Moreover, we report the downregulation of PRDM5 protein expression in human colon neoplastic lesions. In summary, our data provide the first causal link between Prdm5 loss and intestinal carcinogenesis, and uncover an extensive and novel PRDM5 target repertoire likely facilitating the tumor-suppressive functions of PRDM5.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.